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Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-11-14 , DOI: 10.1038/s41598-019-53424-7 Zaida Zainal 1 , Afiqah Abdul Rahim 1 , Ammu Kutty Radhakrishnan 2 , Sui Kiat Chang 3, 4 , Huzwah Khaza'ai 5
Scientific Reports ( IF 3.8 ) Pub Date : 2019-11-14 , DOI: 10.1038/s41598-019-53424-7 Zaida Zainal 1 , Afiqah Abdul Rahim 1 , Ammu Kutty Radhakrishnan 2 , Sui Kiat Chang 3, 4 , Huzwah Khaza'ai 5
Affiliation
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The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint inflammatory disease characterised by severe joint pain, cartilage destruction, and bone erosion owing to the effects of various pro-inflammatory mediators and cytokines. Here, we investigated the therapeutic effects of TRF in a rat model of collagen-induced arthritis (CIA). Arthritis was induced by a single intradermal injection of collagen type II in Dark Agouti (DA) rats. Rats were then treated with or without TRF by oral gavage from day 28 after the first collagen injection. Arthritic rats supplemented with TRF showed decreased articular index scores, ankle circumferences, paw volumes, and radiographic scores when compared with untreated rats. The untreated arthritic rats showed higher plasma C-reactive protein levels (p < 0.05) and production of pro-inflammatory cytokines than arthritic rats fed TRF. Moreover, there was a marked reduction in the severity of histopathological changes observed in arthritic rats treated with TRF compared with that in untreated arthritic rats. Overall, the results show that TRF had beneficial effects in this rat model of RA.
中文翻译：
棕榈维生素E生育三烯酚对自身免疫性关节炎疾病的体内疗效研究。
来自棕榈油的富含生育三烯酚的馏分（TRF）含有维生素E，它具有有效的抗氧化剂和抗炎活性。类风湿关节炎（RA）是一种慢性关节炎性疾病，由于各种促炎性介质和细胞因子的作用，其特征是严重的关节疼痛，软骨破坏和骨质侵蚀。在这里，我们研究了TRF在胶原诱导的关节炎（CIA）大鼠模型中的治疗作用。通过在Dark Agouti（DA）大鼠中一次皮内注射II型胶原来诱发关节炎。从第一次胶原注射后的第28天开始，通过口服强饲法对大鼠进行TRF治疗或不进行TRF治疗。与未治疗的大鼠相比，补充有TRF的关节炎大鼠的关节指数评分，踝围，脚掌体积和X线照相评分降低。与喂食TRF的关节炎大鼠相比，未治疗的关节炎大鼠表现出更高的血浆C反应蛋白水平（p <0.05）和促炎性细胞因子的产生。而且，与未治疗的关节炎大鼠相比，用TRF治疗的关节炎大鼠中观察到的组织病理学改变的严重性显着降低。总体而言，结果表明TRF在该RA大鼠模型中具有有益的作用。
更新日期：2019-11-14
中文翻译：
棕榈维生素E生育三烯酚对自身免疫性关节炎疾病的体内疗效研究。
来自棕榈油的富含生育三烯酚的馏分（TRF）含有维生素E，它具有有效的抗氧化剂和抗炎活性。类风湿关节炎（RA）是一种慢性关节炎性疾病，由于各种促炎性介质和细胞因子的作用，其特征是严重的关节疼痛，软骨破坏和骨质侵蚀。在这里，我们研究了TRF在胶原诱导的关节炎（CIA）大鼠模型中的治疗作用。通过在Dark Agouti（DA）大鼠中一次皮内注射II型胶原来诱发关节炎。从第一次胶原注射后的第28天开始，通过口服强饲法对大鼠进行TRF治疗或不进行TRF治疗。与未治疗的大鼠相比，补充有TRF的关节炎大鼠的关节指数评分，踝围，脚掌体积和X线照相评分降低。与喂食TRF的关节炎大鼠相比，未治疗的关节炎大鼠表现出更高的血浆C反应蛋白水平（p <0.05）和促炎性细胞因子的产生。而且，与未治疗的关节炎大鼠相比，用TRF治疗的关节炎大鼠中观察到的组织病理学改变的严重性显着降低。总体而言，结果表明TRF在该RA大鼠模型中具有有益的作用。
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