High-Performance Quinoline-Malononitrile Core as a Building Block for the Diversity-Oriented Synthesis of AIEgens.,Angewandte Chemie International Edition

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High-Performance Quinoline-Malononitrile Core as a Building Block for the Diversity-Oriented Synthesis of AIEgens.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-11-14 , DOI: 10.1002/anie.201913249
Zhiqian Guo ₁ , Chenxu Yan ₁ , Wei-Hong Zhu ₁

Affiliation

In vivo fluorescent monitoring of physiological processes with high‐fidelity is essential in disease diagnosis and biological research, but faces extreme challenges due to aggregation‐caused quenching (ACQ) and short‐wavelength fluorescence. The development of high‐performance and long‐wavelength aggregation‐induced emission (AIE) fluorophores is in high demand for precise optical bioimaging. The chromophore quinoline‐malononitrile (QM) has recently emerged as a new class of AIE building block that possesses several notable features, such as red to near‐infrared (NIR) emission, high brightness, marked photostability, and good biocompatibility. In this minireview, we summarize some recent advances of our established AIE building block of QM, focusing on the AIE mechanism, regulation of emission wavelength and morphology, the facile scale‐up and fast preparation for AIE nanoparticles, as well as potential biomedical imaging applications.

中文翻译：

高性能喹啉-丙二腈核心作为AIEgens多样性导向合成的基础。

在疾病诊断和生物学研究中，以高保真度进行体内荧光监测是必不可少的，但是由于聚集引起的猝灭（ACQ）和短波长荧光，面临着严峻的挑战。高性能和长波长聚集诱导发射（AIE）荧光团的开发对精确的光学生物成像有很高的要求。发色团喹啉-丙二腈（QM）最近作为一种新型的AIE构建基块而出现，它具有一些显着的特征，例如红色至近红外（NIR）发射，高亮度，显着的光稳定性和良好的生物相容性。在这份小型回顾中，我们总结了已建立的QM AIE构建块的一些最新进展，重点是AIE机制，发射波长和形态的调节，

更新日期：2019-11-14

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