当前位置:
X-MOL 学术
›
Adv. Funct. Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
GSH‐Depleted PtCu3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-11-13 , DOI: 10.1002/adfm.201907954
Xiaoyan Zhong 1 , Xianwen Wang 2 , Liang Cheng 2 , Yong'an Tang 3 , Guiting Zhan 1 , Fei Gong 2 , Rui Zhang 2 , Jun Hu 1 , Zhuang Liu 2 , Xiangliang Yang 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-11-13 , DOI: 10.1002/adfm.201907954
Xiaoyan Zhong 1 , Xianwen Wang 2 , Liang Cheng 2 , Yong'an Tang 3 , Guiting Zhan 1 , Fei Gong 2 , Rui Zhang 2 , Jun Hu 1 , Zhuang Liu 2 , Xiangliang Yang 1
Affiliation
![]() |
The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome of chemodynamic therapy (CDT)‐enhanced sonodynamic therapy (SDT) by depleting GSH is full of great challenge. Herein, PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, PtCu3 nanocages can act as horseradish peroxidase‐like nanozymes, catalyzing the decomposition of H2O2 into •OH under acidic conditions for CDT. Surprisingly, PtCu3 nanocages can act as another kind of nanozyme, mimicking glutathione peroxidase (GSH‐Px), which plays an important role in accelerating GSH depletion by oxidizing molecules, further weakening the capacity of tumor cells scavenging ROS by GSH. Both in vitro and in vivo studies demonstrate that PtCu3 nanocages perform well in reducing GSH level for CDT‐enhanced SDT. Moreover, utilizing the high absorption in the near‐infrared region and strong X‐ray attenuation ability, the PtCu3 nanocages are able to conduct photoacoustic/computed tomography dual‐modal imaging‐guided combined cancer therapy. It is worth mentioning that PtCu3 nanocages cause minimal toxicity to normal tissues at therapeutic doses. This work highlights the use of PtCu3 nanocages for effective CDT‐enhanced SDT via GSH depletion.
中文翻译:
GSH耗尽的PtCu3纳米笼用于化学动力学增强的声动力学癌症治疗
肿瘤中谷胱甘肽(GSH)的超高浓度破坏了基于活性氧(ROS)的疗法,通过消耗GSH改善化学动力学疗法(CDT)增强的声动力学疗法(SDT)的结果充满了巨大挑战。本文中,首先报道了PtCu 3纳米笼在超声辐射下起声敏剂的作用,并具有高效的ROS生成。此外,PtCu 3纳米笼可以充当辣根过氧化物酶样的纳米酶,在酸性条件下催化CDT将H 2 O 2分解成• OH。令人惊讶的是,PtCu 3纳米笼可以充当另一种纳米酶,模仿谷胱甘肽过氧化物酶(GSH-Px),其在通过氧化分子来加速GSH耗竭方面起着重要作用,进一步削弱了肿瘤细胞通过GSH清除ROS的能力。体外和体内研究均表明,PtCu 3纳米笼在降低CDT增强SDT的GSH水平方面表现良好。此外,PtCu 3纳米笼利用近红外区的高吸收和强大的X射线衰减能力,能够进行光声/计算机断层扫描双模态成像指导的联合癌症治疗。值得一提的是,PtCu 3纳米笼在治疗剂量下对正常组织的毒性很小。这项工作强调了PtCu 3的使用 通过GSH耗尽实现有效CDT增强SDT的纳米笼。
更新日期:2020-01-24
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
GSH耗尽的PtCu3纳米笼用于化学动力学增强的声动力学癌症治疗
肿瘤中谷胱甘肽(GSH)的超高浓度破坏了基于活性氧(ROS)的疗法,通过消耗GSH改善化学动力学疗法(CDT)增强的声动力学疗法(SDT)的结果充满了巨大挑战。本文中,首先报道了PtCu 3纳米笼在超声辐射下起声敏剂的作用,并具有高效的ROS生成。此外,PtCu 3纳米笼可以充当辣根过氧化物酶样的纳米酶,在酸性条件下催化CDT将H 2 O 2分解成• OH。令人惊讶的是,PtCu 3纳米笼可以充当另一种纳米酶,模仿谷胱甘肽过氧化物酶(GSH-Px),其在通过氧化分子来加速GSH耗竭方面起着重要作用,进一步削弱了肿瘤细胞通过GSH清除ROS的能力。体外和体内研究均表明,PtCu 3纳米笼在降低CDT增强SDT的GSH水平方面表现良好。此外,PtCu 3纳米笼利用近红外区的高吸收和强大的X射线衰减能力,能够进行光声/计算机断层扫描双模态成像指导的联合癌症治疗。值得一提的是,PtCu 3纳米笼在治疗剂量下对正常组织的毒性很小。这项工作强调了PtCu 3的使用 通过GSH耗尽实现有效CDT增强SDT的纳米笼。