Developing a novel nanofibrous wound dressing with multi-functional properties, integrating suitable mechanical property, electroactivity, anti-oxidant and inherent antibacterial activity to promote wound healing process is urgently desired, which could meet the increasing requirements of clinical needs. Herein, a series of antibacterial, anti-oxidant and electroactive nanofibrous membranes were fabricated by electrospinning poly(ε-caprolactone) (PCL) and quaternized chitosan-graft-polyaniline (QCSP) polymer solutions which combined the good mechanical property of PCL and multi-functionality of QCSP. The nanofibrous wound dressings exhibited electroactivity, similar mechanical properties to soft tissue, free radical scavenging capacity, antibacterial property, and biocompatibility. In particular, PCL/QCSP15 (15wt% of QCSP in the sample) showed a good balanced ability between antibacterial activity and cell proliferation, which significantly accelerated the healing process of wound in a mouse full-thickness wounds defect model than commercial dressing (Tegaderm^TM Film) and pure PCL (PCL/QCSP0) nanofibrous membrane. Moreover, the histopathological examination and immunofluorescence staining showed that the wounds treated by PCL/QCSP15 nanofiber dressing exhibited higher collagen deposition, granulation tissue thickness, and more angiogenesis. In one word, these antibacterial, anti-oxidant, electroactivity nanofibrous membranes showed promising applications for full-thickness skin repair.

迫切需要开发一种具有多功能性能，整合合适的机械性能，电活性，抗氧化剂和固有的抗菌活性以促进伤口愈合过程的新型纳米纤维伤口敷料，这可以满足日益增长的临床需求。本文通过电纺聚（ε-己内酯）（PCL）和季铵化的壳聚糖接枝聚苯胺（QCSP）聚合物溶液制备了一系列抗菌，抗氧化剂和电活性纳米纤维膜，这些溶液结合了PCL和多酚QCSP的功能。纳米纤维伤口敷料具有电活性，与软组织相似的机械性能，清除自由基的能力，抗菌性能和生物相容性。特别是，^TM Film）和纯PCL（PCL / QCSP0）纳米纤维膜。此外，组织病理学检查和免疫荧光染色显示，用PCL / QCSP15纳米纤维敷料处理的伤口表现出更高的胶原蛋白沉积，肉芽组织厚度和更多的血管生成。简而言之，这些抗菌，抗氧化剂，电活性纳米纤维膜在全层皮肤修复中显示出了有希望的应用。