Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography,Organic Process Research & Development

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Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2019-11-12 , DOI: 10.1021/acs.oprd.9b00406
Stuart A. McNelles ₁ , Julia L. Pantaleo ₁ , Alex Adronov ₁

Affiliation

The synthesis of 4-[11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl]-4-oxobutanoic acid, also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne (ADIBO), was optimized for large-scale preparations of at least 10 g with an overall yield of 42%.

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