Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles,ACS Omega

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Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles
ACS Omega ( IF 3.7 ) Pub Date : 2019-10-29 , DOI: 10.1021/acsomega.9b02679
Song Zou ₁ , Yu Liu ₂ , Chanjuan Xi ₁

Affiliation

MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale.

中文翻译：

MeOTf诱导的N-（2-氰基芳基）吲哚环化反应的简捷高效合成吲哚-吲哚酮骨架

MeOTf触发的N-（2-氰基芳基）吲哚的环化反应可提供吲哚[1,2 - a ]吲哚-10-亚胺，相应的吲哚[1,2 - a ]吲哚-10酮已在金属-免费条件。各种功能基团在其支架中均具有良好至极佳的产量。该反应可以进行至克级。

更新日期：2019-11-13

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