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An integrative framework for perceptual disturbances in psychosis.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-12-01 , DOI: 10.1038/s41583-019-0234-1
Guillermo Horga 1 , Anissa Abi-Dargham 2
Affiliation  

Perceptual disturbances in psychosis, such as auditory verbal hallucinations, are associated with increased baseline activity in the associative auditory cortex and increased dopamine transmission in the associative striatum. Perceptual disturbances are also associated with perceptual biases that suggest increased reliance on prior expectations. We review theoretical models of perceptual inference and key supporting physiological evidence, as well as the anatomy of associative cortico-striatal loops that may be relevant to auditory perceptual inference. Integrating recent findings, we outline a working framework that bridges neurobiology and the phenomenology of perceptual disturbances via theoretical models of perceptual inference.

中文翻译:

精神病知觉障碍的综合框架。

精神病中的知觉障碍,例如听觉幻觉,与联想听觉皮层的基线活动增加和联想纹状体中的多巴胺传递增加有关。知觉障碍也与知觉偏差有关,这表明对先前期望的依赖增加。我们回顾了知觉推理的理论模型和支持生理学证据的关键,以及可能与听觉知觉推理相关的相关皮质纹状体环的解剖结构。综合最近的发现,我们概述了一个工作框架,该框架通过知觉推理的理论模型将神经生物学和知觉障碍的现象学联系起来。
更新日期:2019-11-11
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