The many functions of ESCRTs.,Nature Reviews Molecular Cell Biology

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The many functions of ESCRTs.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-11-08 , DOI: 10.1038/s41580-019-0177-4
Marina Vietri _{1,

2} , Maja Radulovic _{1,

2} , Harald Stenmark _{1,

2,

3}

Affiliation

Cellular membranes can form two principally different involutions, which either exclude or contain cytosol. The 'classical' budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, involve proteins that assemble on the cytosol-excluding face of the bud neck. Inverse membrane involution occurs in a wide range of cellular processes, supporting cytokinesis, endosome maturation, autophagy, membrane repair and many other processes. Such inverse membrane remodelling is mediated by a heteromultimeric protein machinery known as endosomal sorting complex required for transport (ESCRT). ESCRT proteins assemble on the cytosolic (or nucleoplasmic) face of the neck of the forming involution and cooperate with the ATPase VPS4 to drive membrane scission or sealing. Here, we review similarities and differences of various ESCRT-dependent processes, with special emphasis on mechanisms of ESCRT recruitment.

中文翻译：

ESCRT 的许多功能。

细胞膜可以形成两种主要不同的复合，它们或者排除或包含胞质溶胶。“经典”出芽反应，例如在胞吞作用或胞吐囊泡形成期间发生的那些反应，涉及在芽颈的细胞质外表面组装的蛋白质。反膜退化发生在广泛的细胞过程中，支持胞质分裂、内体成熟、自噬、膜修复和许多其他过程。这种逆膜重塑由称为转运所需的内体分选复合物 (ESCRT) 的异多聚体蛋白质机器介导。ESCRT 蛋白聚集在形成对合颈部的胞质（或核质）面上，并与 ATPase VPS4 合作以驱动膜断裂或密封。这里，

更新日期：2019-11-08

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