Neisseria meningitidis: using genomics to understand diversity, evolution and pathogenesis.,Nature Reviews Microbiology

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Neisseria meningitidis: using genomics to understand diversity, evolution and pathogenesis.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2019-11-08 , DOI: 10.1038/s41579-019-0282-6
Dominique A Caugant _{1,

2} , Ola B Brynildsrud _{1,

3}

Affiliation

Meningococcal disease remains an important cause of morbidity and death worldwide despite the development and increasing implementation of effective vaccines. Elimination of the disease is hampered by the enormous diversity and antigenic variability of the causative agent, Neisseria meningitidis, one of the most variable bacteria in nature. These features are attained mainly through high rates of horizontal gene transfer and alteration of protein expression through phase variation. The recent availability of whole-genome sequencing (WGS) of large-scale collections of N. meningitidis isolates from various origins, databases to facilitate storage and sharing of WGS data and the concomitant development of effective bioinformatics tools have led to a much more thorough understanding of the diversity of the species, its evolution and population structure and how virulent traits may emerge. Implementation of WGS is already contributing to enhanced epidemiological surveillance and is essential to ascertain the impact of vaccination strategies. This Review summarizes the recent advances provided by WGS studies in our understanding of the biology of N. meningitidis and the epidemiology of meningococcal disease.

中文翻译：

脑膜炎奈瑟氏球菌：利用基因组学来了解多样性，进化和发病机理。

尽管开发和增加了有效疫苗的使用，脑膜炎球菌疾病仍然是全世界发病率和死亡的重要原因。病原体脑膜炎奈瑟氏球菌是自然界中最易变的细菌之一，其巨大的多样性和抗原变异性阻碍了该病的消除。这些特征主要是通过高水平水平基因转移和通过相变改变蛋白质表达来实现的。来自不同来源的大规模脑膜炎双球菌分离株全基因组测序（WGS）的最新可用性，有助于存储和共享WGS数据的数据库以及有效的生物信息学工具的伴随开发已使人们有了更透彻的了解该物种的多样性它的进化和种群结构，以及如何出现强毒特征。WGS的实施已经为加强流行病学监测做出了贡献，对于确定疫苗接种策略的影响至关重要。这篇综述总结了WGS研究在我们对脑膜炎奈瑟氏球菌的生物学和脑膜炎球菌疾病流行病学的理解方面提供的最新进展。

更新日期：2019-11-08

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