Magnetic nanoparticle (MNP) assemblies have demonstrated great potential in biomedical applications due to their controllable magnetic properties and collective functions. Among the versatile approaches to obtaining MNP assemblies, polymer-assisted assembling methods offer unique advances, by which the assembled nanostructures could exert the merits of both the inorganic magnetic nanoparticles and organic polymeric materials to realize combined advantages for medical diagnosis and treatment. Precise control over the interactions among different building moieties and spatial organization of magnetic nanoparticles with the aid of polymers provides promising strategies in manipulating the physical, chemical, and biological properties of nanoassemblies for biomedical applications. In this review, we summarize the recent progress of polymer-assisted MNP assemblies, which include the mutual interactions between building blocks, architectural diversity of the assemblies, and their synthetic strategies along with biomedical applications. The current review provides a comprehensive insight into controlled and intelligent nanomedicines, which shall facilitate the development of next-generation high-performance theranostic agents based on MNP assemblies.

中文翻译：

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用于生物医学应用的聚合物辅助磁性纳米粒子组件

磁性纳米粒子 (MNP) 组件由于其可控的磁性和集体功能而在生物医学应用中显示出巨大的潜力。在获得 MNP 组件的多种方法中，聚合物辅助组装方法提供了独特的进步，通过这种方法组装的纳米结构可以发挥无机磁性纳米粒子和有机聚合物材料的优点，从而实现医学诊断和治疗的综合优势。借助聚合物精确控制磁性纳米粒子的不同结构部分和空间组织之间的相互作用，为控制生物医学应用中纳米组件的物理、化学和生物特性提供了有前景的策略。在本次审查中，我们总结了聚合物辅助 MNP 组件的最新进展，包括构建块之间的相互作用、组件的结构多样性及其合成策略以及生物医学应用。目前的审查提供了对受控和智能纳米药物的全面洞察，这将有助于开发基于 MNP 组件的下一代高性能治疗剂。