当前位置：
X-MOL 学术
›
Transl. Psychiaty
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks.
Translational Psychiatry ( IF 5.8 ) Pub Date : 2019-11-07 , DOI: 10.1038/s41398-019-0617-0 Gaia Olivo 1 , Christina Zhukovsky 1 , Helena Salonen-Ros 2 , Elna-Marie Larsson 3 , Samantha Brooks 1, 4, 5 , Helgi B Schiöth 1, 6
Translational Psychiatry ( IF 5.8 ) Pub Date : 2019-11-07 , DOI: 10.1038/s41398-019-0617-0 Gaia Olivo 1 , Christina Zhukovsky 1 , Helena Salonen-Ros 2 , Elna-Marie Larsson 3 , Samantha Brooks 1, 4, 5 , Helgi B Schiöth 1, 6
Affiliation
|
Atypical anorexia nervosa (AN) usually occurs during adolescence. Patients are often in the normal-weight range at diagnosis; however, they often present with signs of medical complications and severe restraint over eating, body dissatisfaction, and low self-esteem. We investigated functional circuitry underlying the hedonic response in 28 female adolescent patients diagnosed with atypical AN and 33 healthy controls. Participants were shown images of food with high (HC) or low (LC) caloric content in alternating blocks during functional MRI. The HC > LC contrast was calculated. Based on the previous literature on full-threshold AN, we hypothesized that patients would exhibit increased connectivity in areas involved in sensory processing and bottom-up responses, coupled to increased connectivity from areas related to top-down inhibitory control, compared with controls. Patients showed increased connectivity in pathways related to multimodal somatosensory processing and memory retrieval. The connectivity was on the other hand decreased in patients in salience and attentional networks, and in a wide cerebello-occipital network. Our study was the first investigation of food-related neural response in atypical AN. Our findings support higher somatosensory processing in patients in response to HC food images compared with controls, however HC food was less efficient than LC food in engaging patients' bottom-up salient responses, and was not associated with connectivity increases in inhibitory control regions. These findings suggest that the psychopathological mechanisms underlying food restriction in atypical AN differ from full-threshold AN. Elucidating the mechanisms underlying the development and maintenance of eating behavior in atypical AN might help designing specific treatment strategies.
中文翻译：
具有非典型AN的女性青少年享乐对食物的反应的功能连接性：体感和显着网络的作用。
非典型神经性厌食症（AN）通常发生在青春期。诊断时患者通常处于正常体重范围内；然而，他们经常表现出医疗并发症的征兆，对进食，身体不满和自尊心的严格克制。我们调查了诊断为非典型AN的28名女性青少年患者和33名健康对照的享乐反应背后的功能电路。在功能性MRI期间，向参与者显示了食物中具有高（HC）或低（LC）热量的食物的图像。计算出HC> LC对比。根据先前有关全阈值AN的文献，我们假设患者在感觉处理和自下而上的反应所涉及的区域中将表现出增强的连通性，同时与自上而下的抑制控制相关的区域中的连通性也会增加，与控件相比。患者在与多模式体感处理和记忆检索有关的途径中显示出增加的连通性。另一方面，在显着性和注意力网络以及广泛的小脑枕网络中，患者的连通性下降。我们的研究是对非典型AN中与食物相关的神经反应的首次调查。我们的发现支持与对照组相比，对HC食物图像响应的患者更高的体感处理能力，但是HC食物在吸引患者自下而上的显着反应方面效率不如LC食物，并且与抑制性对照区域的连通性增加无关。这些发现表明，非典型性AN中食物限制的心理病理学机制与全阈值AN不同。
更新日期：2019-11-07
中文翻译：
具有非典型AN的女性青少年享乐对食物的反应的功能连接性：体感和显着网络的作用。
非典型神经性厌食症（AN）通常发生在青春期。诊断时患者通常处于正常体重范围内；然而，他们经常表现出医疗并发症的征兆，对进食，身体不满和自尊心的严格克制。我们调查了诊断为非典型AN的28名女性青少年患者和33名健康对照的享乐反应背后的功能电路。在功能性MRI期间，向参与者显示了食物中具有高（HC）或低（LC）热量的食物的图像。计算出HC> LC对比。根据先前有关全阈值AN的文献，我们假设患者在感觉处理和自下而上的反应所涉及的区域中将表现出增强的连通性，同时与自上而下的抑制控制相关的区域中的连通性也会增加，与控件相比。患者在与多模式体感处理和记忆检索有关的途径中显示出增加的连通性。另一方面，在显着性和注意力网络以及广泛的小脑枕网络中，患者的连通性下降。我们的研究是对非典型AN中与食物相关的神经反应的首次调查。我们的发现支持与对照组相比，对HC食物图像响应的患者更高的体感处理能力，但是HC食物在吸引患者自下而上的显着反应方面效率不如LC食物，并且与抑制性对照区域的连通性增加无关。这些发现表明，非典型性AN中食物限制的心理病理学机制与全阈值AN不同。
京公网安备 11010802027423号