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Type H blood vessels in bone modeling and remodeling.
Theranostics ( IF 12.4 ) Pub Date : 2020-01-01 , DOI: 10.7150/thno.34126
Yi Peng 1 , Song Wu 1 , Yusheng Li 2 , Janet L Crane 3
Affiliation  

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bone formation. Type H vessels, termed such because of high expression of Endomucin (Emcn) and CD31, have recently been identified and have the ability to induce bone formation. Factors including platelet-derived growth factor type BB (PDGF-BB), slit guidance ligand 3 (SLIT3), hypoxia-inducible factor 1-alpha (HIF-1α), Notch, and vascular endothelial growth factor (VEGF) are involved in the coupling of angiogenesis and osteogenesis. This review summarizes the current understanding of signaling pathways that regulate type H vessels and how type H vessels modulate osteogenesis. Further studies dissecting the regulation and function of type H vessels will provide new insights into the role of bone vasculature in the metabolism of the skeleton. We also discuss considerations for therapeutic approaches targeting type H vessels to promote fracture healing, prevent pathological bone loss, osteonecrosis, osteoarthritis, and bone metastases.



中文翻译:

H 型血管在骨建模和重塑中的应用。

在哺乳动物骨骼系统中,骨生成和血管生成在骨建模中的骨生长和再生期间以及骨重塑中的骨稳态期间密切相关。最近的研究扩展了我们对血管生成和骨形成耦合的分子和细胞机制的认识。H 型血管由于内粘蛋白 (Emcn) 和 CD31 的高表达而得名,最近已被鉴定出具有诱导骨形成的能力。血小板源性生长因子 BB 型 (PDGF-BB)、狭缝引导配体 3 (SLIT3)、缺氧诱导因子 1-α (HIF-1α)、Notch 和血管内皮生长因子 (VEGF) 等因子参与该过程。血管生成和骨生成的耦合。这篇综述总结了目前对调节 H 型血管的信号通路以及 H 型血管如何调节成骨的理解。剖析 H 型血管的调节和功能的进一步研究将为骨血管系统在骨骼代谢中的作用提供新的见解。我们还讨论了针对 H 型血管的治疗方法的注意事项,以促进骨折愈合,预防病理性骨丢失、骨坏死、骨关节炎和骨转移。

更新日期:2020-01-01
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