Cell-Encapsulating Hydrogel Puzzle: Polyrotaxane-Based Self-Healing Hydrogels.,Chemistry - A European Journal

当前位置： X-MOL 学术 › Chem. Eur. J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cell-Encapsulating Hydrogel Puzzle: Polyrotaxane-Based Self-Healing Hydrogels.
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-12-18 , DOI: 10.1002/chem.201904446
Ik Sung Cho ₁ , Tooru Ooya ₁

Affiliation

Slide-ring hydrogels using polyrotaxanes have been developed as highly tough soft materials. However, they have never been used as biomaterials because of the lack of biocompatibility. Meanwhile, self-healing hydrogels are expected to improve fatigue resistance and extend the period of use. However, owing to the lack of high mechanical strength, they are limited in their use as biomaterials. Here we first developed a biocompatible self-healing/slide-ring hydrogel using glycol chitosan and a water-soluble polyrotaxane. We obtained excellent mechanical toughness and biocompatibility to promote the proliferation of human umbilical vein endothelial cells (HUVECs) encapsulated in the hydrogel. Owing to the rapid self-healing property, the cell-encapsulating gels adjusted arbitrarily, maintaining good cell proliferation function. Therefore, slide-ring hydrogels enable the use of biomaterials for soft-tissue engineering.

中文翻译：

细胞包裹水凝胶难题：基于聚轮烷的自修复水凝胶。

使用聚轮烷的滑环水凝胶已被开发为高韧性的软质材料。但是，由于缺乏生物相容性，它们从未被用作生物材料。同时，自修复水凝胶有望改善抗疲劳性并延长使用期限。然而，由于缺乏高机械强度，它们在用作生物材料方面受到限制。在这里，我们首先使用乙二醇壳聚糖和水溶性聚轮烷开发了生物相容性自修复/滑环水凝胶。我们获得了优异的机械韧性和生物相容性，以促进封装在水凝胶中的人脐静脉内皮细胞（HUVEC）的增殖。由于具有快速的自我修复性能，因此可以任意调节细胞封装凝胶，从而保持良好的细胞增殖功能。所以，

更新日期：2019-12-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文