Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.,British Journal of Cancer

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Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.
British Journal of Cancer ( IF 6.4 ) Pub Date : 2019-11-06 , DOI: 10.1038/s41416-019-0623-2
Moritz Jesinghaus _{1,

2,

3} , Melanie Boxberg ₁ , Dirk Wilhelm ₄ , Stefan Münch _{2,

5} , Hendrik Dapper ₅ , Michael Quante ₆ , Christoph Schlag ₆ , Sebastian Lange ₆ , Jan Budczies ₇ , Björn Konukiewitz ₁ , Martin Mollenhauer ₁ , Anna Melissa Schlitter ₁ , Karl Friedrich Becker ₁ , Marcus Feith ₄ , Helmut Friess ₄ , Katja Steiger ₁ , Stephanie E Combs _{2,

5,

8} , Wilko Weichert _{1,

2}

Affiliation

BACKGROUND Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy. METHODS We evaluated cell nest size and tumour budding activity in 122 post-neoadjuvant ESCC resections, correlated the results with tumour regression groups and patient survival and compared the results with data from primary resected cases as well as pre-therapeutic biopsies. RESULTS CDG remained stable when results from pre-therapeutic biopsies and post-therapeutic resections from the same patient were compared. CDG was associated with therapy response and a strong predictor of overall, disease-specific (DSS) and disease-free (DFS) survival in univariate analysis and-besides metastasis-remained the only significant survival predictor for DSS and DFS in multivariate analysis. Multivariate DFS hazard ratios reached 3.3 for CDG-G2 and 4.9 for CDG-G3 neoplasms compared with CDG-G1 carcinomas (p = 0.016). CONCLUSIONS CDG is the only morphology-based grading algorithm published to date, which in concert with regression grading, is able to contribute relevant prognostic information in the post-neoadjuvant setting of ESCC.

中文翻译：

基于肿瘤萌芽和细胞巢大小的新辅助后细胞解离分级与食管鳞状细胞癌的治疗反应和生存有关。

背景技术由肿瘤发芽和细胞巢大小组成的细胞分离度（CDG）已被证明可独立预测食管鳞状细胞癌（ESCC）的治疗前活检和主要切除的预后。在这里，我们旨在评估CDG在新辅助治疗后对ESCC的预后影响。方法我们评估了122例新辅助术后ESCC切除的细胞巢大小和肿瘤萌发活性，将结果与肿瘤消退组和患者生存率相关联，并将结果与主要切除病例以及治疗前活检的数据进行了比较。结果比较来自同一患者的治疗前活检和治疗后切除的结果，CDG保持稳定。CDG与治疗反应相关，并且是整体，单变量分析中疾病特异性（DSS）和无病（DFS）生存率以及转移率仍然是多变量分析中DSS和DFS唯一重要的生存预测指标。与CDG-G1癌相比，CDG-G2的多变量DFS危险比达到3.3，CDG-G3肿瘤达到4.9（p = 0.016）。结论CDG是迄今为止唯一基于形态学的分级算法，该算法与回归分级相结合，能够在ESCC的新辅助治疗后提供相关的预后信息。

更新日期：2019-11-05

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