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Management of functional constipation in children and adults.
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2019-11-05 , DOI: 10.1038/s41575-019-0222-y
Mana H Vriesman 1 , Ilan J N Koppen 1 , Michael Camilleri 2 , Carlo Di Lorenzo 3 , Marc A Benninga 1
Affiliation  

Functional constipation is common in children and adults worldwide. Functional constipation shows similarities in children and adults, but important differences also exist regarding epidemiology, symptomatology, pathophysiology, diagnostic workup and therapeutic management. In children, the approach focuses on the behavioural nature of the disorder and the initial therapeutic steps involve toilet training and laxatives. In adults, management focuses on excluding an underlying cause and differentiating between different subtypes of functional constipation - normal transit, slow transit or an evacuation disorder - which has important therapeutic consequences. Treatment of adult functional constipation involves lifestyle interventions, pelvic floor interventions (in the presence of a rectal evacuation disorder) and pharmacological therapy. When conventional treatments fail, children and adults are considered to have intractable functional constipation, a troublesome and distressing condition. Intractable constipation is managed with a stepwise approach and in rare cases requires surgical interventions such as antegrade continence enemas in children or colectomy procedures for adults. New drugs, including prokinetic and prosecretory agents, and surgical strategies, such as sacral nerve stimulation, have the potential to improve the management of children and adults with intractable functional constipation.

中文翻译:

儿童和成人功能性便秘的管理。

功能性便秘在全世界的儿童和成人中很常见。功能性便秘在儿童和成人中表现出相似之处,但在流行病学、症状学、病理生理学、诊断检查和治疗管理方面也存在重要差异。在儿童中,该方法侧重于疾病的行为性质,最初的治疗步骤包括如厕训练和泻药。在成人中,管理的重点是排除根本原因并区分功能性便秘的不同亚型——正常运输、缓慢运输或排空障碍——这具有重要的治疗效果。成人功能性便秘的治疗包括生活方式干预、盆底干预(存在直肠排空障碍)和药物治疗。当常规治疗失败时,儿童和成人被认为患有顽固的功能性便秘,这是一种麻烦且令人痛苦的状况。顽固性便秘采用逐步方法进行管理,在极少数情况下需要手术干预,例如儿童顺行失禁灌肠或成人结肠切除术。新药,包括促动力剂和促分泌剂,以及手术策略,如骶神经刺激,有可能改善患有顽固性功能性便秘的儿童和成人的治疗。顽固性便秘采用逐步方法进行管理,在极少数情况下需要手术干预,例如儿童顺行失禁灌肠或成人结肠切除术。新药,包括促动力剂和促分泌剂,以及手术策略,如骶神经刺激,有可能改善患有顽固性功能性便秘的儿童和成人的治疗。顽固性便秘采用逐步方法进行管理,在极少数情况下需要手术干预,例如儿童顺行失禁灌肠或成人结肠切除术。新药,包括促动力剂和促分泌剂,以及手术策略,如骶神经刺激,有可能改善患有顽固性功能性便秘的儿童和成人的治疗。
更新日期:2019-11-05
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