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A self-healable and antifouling hydrogel based on PDMS centered ABA tri-block copolymer polymersomes: a potential material for therapeutic contact lenses.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-12-02 , DOI: 10.1039/c9tb00949c Sovan Lal Banerjee 1 , Sarthik Samanta 1 , Shrabana Sarkar 1 , Nikhil K Singha 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-12-02 , DOI: 10.1039/c9tb00949c Sovan Lal Banerjee 1 , Sarthik Samanta 1 , Shrabana Sarkar 1 , Nikhil K Singha 1
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Herein we have prepared an antifouling and self-healable poly(dimethyl siloxane) (PDMS) based hydrogel which consists of a mixture of curcumin loaded zwitterionic PDMS polymersomes and amine functionalized PDMS polymersomes prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization and a Schiff-base reaction. The curcumin loaded polymersome consists of a PDMS and poly([dimethyl-[3-(2-methyl-acryloylamino)-propyl]-(3-sulfopropyl)ammonium)] (poly(sulfobetaine)) based tri-block copolymer (BCP) and it was characterized by dynamic light scattering (DLS), high resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) analyses. To prepare the hydrogel, amine functionalized PDMS polymersomes were crosslinked with polyethylene glycol dialdehyde (PEG-DA) in pH 7.4 buffer solution via a Schiff-base reaction. This hydrogel was able to show sustained delivery of the entrapped curcumin drug for more than 72 h. The self-healing characteristic of the prepared hydrogel in the presence of saline water was elucidated by the "scratch and heal" method and subsequently analyzed through tensile study. Due to the presence of the poly(zwitterionic) moiety in the hydrogel system, it was observed that the hydrogel can efficiently reduce protein deposition, where Bovine Serum Albumin (BSA) was taken as a model protein. It was observed that the curcumin loaded hydrogel was detrimental towards both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. This type of smart soft hydrogel system can be a potential material for therapeutic applications for several eye diseases.
中文翻译：
基于PDMS的ABA三嵌段共聚物聚合物囊泡的自修复防污水凝胶：治疗性隐形眼镜的潜在材料。
本文中，我们制备了一种防污和自修复的聚二甲基硅氧烷（PDMS）基水凝胶，该凝胶由姜黄素负载的两性离子PDMS聚合物囊泡和胺官能化PDMS聚合物囊泡的混合物组成，该混合物通过可逆加成-断裂链转移（RAFT）聚合反应制备，席夫碱反应。载有姜黄素的聚合物囊泡由PDMS和基于三嵌段共聚物（BCP）的聚[[二甲基-[3-（2-甲基-丙烯酰基氨基）-丙基]-（3-磺基丙基）铵）[聚（磺基甜菜碱）]组成它的特点是动态光散射（DLS），高分辨率透射电子显微镜（HRTEM），场发射扫描电子显微镜（FESEM）和原子力显微镜（AFM）分析。要准备水凝胶，胺官能化的PDMS聚合物囊泡通过席夫碱反应在pH 7.4缓冲溶液中与聚乙二醇二醛（PEG-DA）交联。这种水凝胶能够显示出包埋的姜黄素药物持续递送超过72小时。通过“刮擦和愈合”方法阐明了在盐水存在下制备的水凝胶的自愈特性，随后通过拉伸研究对其进行了分析。由于水凝胶系统中存在聚（两性离子）部分，因此观察到水凝胶可以有效地减少蛋白质沉积，其中牛血清白蛋白（BSA）被用作模型蛋白质。观察到，载有姜黄素的水凝胶对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌均有害。
更新日期：2020-01-02
中文翻译：
基于PDMS的ABA三嵌段共聚物聚合物囊泡的自修复防污水凝胶：治疗性隐形眼镜的潜在材料。
本文中，我们制备了一种防污和自修复的聚二甲基硅氧烷（PDMS）基水凝胶，该凝胶由姜黄素负载的两性离子PDMS聚合物囊泡和胺官能化PDMS聚合物囊泡的混合物组成，该混合物通过可逆加成-断裂链转移（RAFT）聚合反应制备，席夫碱反应。载有姜黄素的聚合物囊泡由PDMS和基于三嵌段共聚物（BCP）的聚[[二甲基-[3-（2-甲基-丙烯酰基氨基）-丙基]-（3-磺基丙基）铵）[聚（磺基甜菜碱）]组成它的特点是动态光散射（DLS），高分辨率透射电子显微镜（HRTEM），场发射扫描电子显微镜（FESEM）和原子力显微镜（AFM）分析。要准备水凝胶，胺官能化的PDMS聚合物囊泡通过席夫碱反应在pH 7.4缓冲溶液中与聚乙二醇二醛（PEG-DA）交联。这种水凝胶能够显示出包埋的姜黄素药物持续递送超过72小时。通过“刮擦和愈合”方法阐明了在盐水存在下制备的水凝胶的自愈特性，随后通过拉伸研究对其进行了分析。由于水凝胶系统中存在聚（两性离子）部分，因此观察到水凝胶可以有效地减少蛋白质沉积，其中牛血清白蛋白（BSA）被用作模型蛋白质。观察到，载有姜黄素的水凝胶对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌均有害。
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