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Lost in (Clinical) Translation: Recent Advances in Heparin Neutralization and Monitoring.
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2019-11-12 , DOI: 10.1021/acschembio.9b00772 Benjamin Ourri 1 , Laurent Vial 1
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2019-11-12 , DOI: 10.1021/acschembio.9b00772 Benjamin Ourri 1 , Laurent Vial 1
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The heparin family, which includes unfractionated heparin, low-molecular heparin, and fondaparinux, is a class of drugs clinically used as intravenous blood thinners. To date, issues related to both the reversal of anticoagulation and the blood level determination of the anticoagulant at the point-of-care remain: while the only U.S. Food and Drug Administration (FDA) approved antidote for heparin displays serious efficacy and safety drawbacks, the current assays for heparin monitoring are indirect measurements subject to their own limitations and variations. Herein, we provide an update on the numerous recent chemical approaches to tackle these issues, from which it is clear that some new antidotes and sensors for heparin certainly have the potential to exceed current clinical standards. This review aims to review a field that requires close collaborations between physicians, biologists, and chemists in order to foster advances toward clinical translation.
中文翻译：
在（临床）翻译中迷失：肝素中和和监测的最新进展。
肝素家族包括普通肝素，低分子肝素和磺达肝素，是临床上用作静脉血稀释剂的一类药物。迄今为止，与抗凝作用的逆转和护理点时抗凝剂的血药浓度测定有关的问题仍然存在：尽管唯一的美国食品药品监督管理局（FDA）批准的肝素解毒剂显示出严重的功效和安全性缺点，当前用于肝素监测的测定法是间接测量法，受其自身局限性和变化的影响。在此，我们提供了解决这些问题的最新化学方法的最新信息，从中可以明显看出，一些新的肝素解毒剂和传感器肯定有可能超过当前的临床标准。
更新日期：2019-11-13
中文翻译：
在（临床）翻译中迷失：肝素中和和监测的最新进展。
肝素家族包括普通肝素，低分子肝素和磺达肝素，是临床上用作静脉血稀释剂的一类药物。迄今为止，与抗凝作用的逆转和护理点时抗凝剂的血药浓度测定有关的问题仍然存在：尽管唯一的美国食品药品监督管理局（FDA）批准的肝素解毒剂显示出严重的功效和安全性缺点，当前用于肝素监测的测定法是间接测量法，受其自身局限性和变化的影响。在此，我们提供了解决这些问题的最新化学方法的最新信息，从中可以明显看出，一些新的肝素解毒剂和传感器肯定有可能超过当前的临床标准。
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