The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.,Nature Communications

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The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.
Nature Communications ( IF 14.7 ) Pub Date : 2019-11-01 , DOI: 10.1038/s41467-019-12847-6
Bo Li _{1,

2} , Marco Aurélio Ferreira _{3,

4} , Mengling Huang _{1,

2} , Luiz Fernando Camargos _{3,

4,

5} , Xiao Yu ₆ , Ruan M Teixeira _{3,

4} , Paola A Carpinetti ₄ , Giselle C Mendes _{3,

4,

7} , Bianca C Gouveia-Mageste ₃ , Chenglong Liu ₆ , Claudia S L Pontes ₃ , Otávio J B Brustolini _{3,

8} , Laura G C Martins _{3,

4} , Bruno P Melo _{3,

4} , Christiane E M Duarte _{3,

4} , Libo Shan ₆ , Ping He ₉ , Elizabeth P B Fontes _{3,

4}

Affiliation

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
National Institute of Science and Technology in Plant-Pest Interactions, Bioagro, Viçosa, MG, 36570.900, Brazil.
Department of Biochemistry and Molecular Biology, Universidade Federal de Viçosa, Viçosa, MG, 36570.900, Brazil.
Federal Institute of Education from Goias, Science and Technology, Urutaí, GO, 75790-000, Brazil.
Department of Plant Pathology and Microbiology, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, 77843, USA.
Instituto Federal de Educação, Ciência e Tecnologia Catarinense, Rio do Sul, SC, 89163-356, Brazil.
Laboratório Nacional de Computação Cientifica (LNCC), Petrópolis, RJ, Brazil.
Department of Biochemistry and Biophysics, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX, 77843, USA.

Plants deploy various immune receptors to recognize pathogens and defend themselves. Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during simultaneous infection of different pathogens. However, the related function of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive. Here, we report that NIK1, which positively regulates plant antiviral immunity, acts as an important negative regulator of antibacterial immunity. nik1 plants exhibit dwarfed morphology, enhanced disease resistance to bacteria and increased PAMP-triggered immunity (PTI) responses, which are restored by NIK1 reintroduction. Additionally, NIK1 negatively regulates the formation of the FLS2/BAK1 complex. The interaction between NIK1 and FLS2/BAK1 is enhanced upon flg22 perception, revealing a novel PTI regulatory mechanism by an RLK. Furthermore, flg22 perception induces NIK1 and RPL10A phosphorylation in vivo, activating antiviral signalling. The NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.

中文翻译：

受体样激酶NIK1靶向FLS2 / BAK1免疫复合物，并反向调节抗病毒和抗菌免疫。

植物会部署各种免疫受体来识别病原体并保护自己。在同时感染不同病原体的过程中，同一宿主中受体介导的信号转导途径之间可能发生串扰。但是，受体样激酶（RLK）在阻止不同病原体方面的相关功能仍然难以捉摸。在这里，我们报告说，正调控植物抗病毒免疫力的NIK1充当着重要的负性抗细菌免疫力调节剂。nik1植物表现出矮小的形态，增强了对细菌的抗病性，并增加了PAMP触发的免疫（PTI）反应，这些都可以通过重新引入NIK1来恢复。此外，NIK1负调控FLS2 / BAK1复合物的形成。通过flg22感知，NIK1和FLS2 / BAK1之间的相互作用得到增强，RLK揭示了一种新颖的PTI调节机制。此外，flg22感知在体内诱导NIK1和RPL10A磷酸化，从而激活抗病毒信号传导。NIK1介导的抗病毒和抗细菌免疫力的逆调制可能使细菌和病毒激活彼此的宿主免疫反应。

更新日期：2019-11-01

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