A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation behavior using Crystal engineering approach. Interestingly, two amides, namely, 3-methyl-N-(thiazol-2-yl) benzamide (1c) and 3-methyl-N-(5-methylthiazol-2-yl) benzamide (3c) displayed gelation behavior towards ethanol/water and methanol/water mixture with good stability and low minimum gelator concentration (MGC). The single crystal structure of gelator (1c) displayed the helical assembly driven by π-π interaction along with cyclic N–H⋯N and S⋯O interaction, whereas single crystal structure of gelator (3c) displayed 2D hydrogen bonded network without any π-π interaction.

合成，表征和研究了一系列新的N-（噻唑-2-基）苯甲酰胺衍生物的胶凝行为，目的是阐明使用晶体的甲基官能团和多种非共价相互作用对胶凝/非胶凝行为的作用。工程方法。有趣的是，两种酰胺，即3-甲基-N-（噻唑-2-基）苯甲酰胺（1c）和3-甲基-N-（5-甲基噻唑-2-基）苯甲酰胺（3c）对乙醇/水和甲醇/水混合物，稳定性好，最低胶凝剂浓度（MGC）低。胶凝剂（1c）的单晶结构显示出由π-π相互作用以及循环的N–H⋯N和S⋯O相互作用驱动的螺旋组装，而胶凝剂（1c）（3c）显示了没有任何π-π相互作用的2D氢键网络。