Mussel-Inspired Multivalent Linear Polyglycerol Coatings Outperform Monovalent Polyethylene Glycol Coatings in Antifouling Surface Properties,ACS Applied Bio Materials

当前位置： X-MOL 学术 › ACS Appl. Bio Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mussel-Inspired Multivalent Linear Polyglycerol Coatings Outperform Monovalent Polyethylene Glycol Coatings in Antifouling Surface Properties
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2019-11-19 , DOI: 10.1021/acsabm.9b00786
Michaël W Kulka ₁ , Ievgen S Donskyi _{1,

2} , Nina Wurzler ₂ , Dirk Salz ₃ , Özlem Özcan ₂ , Wolfgang E S Unger ₂ , Rainer Haag ₁

Affiliation

Biofouling constitutes a major challenge in the application of biosensors and biomedical implants, as well as for (food) packaging and marine equipment. In this work, an antifouling surface coating based on the combination of mussel-inspired dendritic polyglycerol (MI-dPG) and an amine-functionalized block copolymer of linear polyglycerol (lPG–b–OA₁₁, OA = oligo-amine) was developed. The coating was compared to a MI-dPG surface which was postfunctionalized with commercially available amine-terminated polyethylene glycol (HO–PEG–NH₂) of similar molecular weight. In the current work, these coatings were compared in their chemical stability, protein fouling characteristics, and cell fouling characteristics. The lPG–b–OA₁₁-functionalized coating showed high chemical stability in both phosphate buffered saline (PBS) and sodium dodecyl sulfate (SDS) solutions and reduced the adhesion of fibrinogen from human plasma with 99% and the adhesion of human serum albumin with 96%, in comparison to the bare titanium dioxide substrate. Furthermore, the proliferation of human umbilical vein endothelial cells (HUVECs) was reduced with 85% when the lPG–b–OA₁₁ system was compared to bare titanium dioxide. Additionally, a reduction of 94% was observed when the lPG–b–OA₁₁ system was compared to tissue culture polystyrene.

中文翻译：

受贻贝启发的多价线性聚甘油涂料在防污表面性能方面优于单价聚乙二醇涂料

生物污染是生物传感器和生物医学植入物以及（食品）包装和海洋设备应用的主要挑战。在这项工作中，开发了一种基于贻贝启发的树枝状聚甘油 (MI-dPG) 和线性聚甘油的胺官能化嵌段共聚物 (lPG-b-OA ₁₁ , OA = oligo-amine) 组合的防污表面涂层。将该涂层与 MI-dPG 表面进行比较，该表面用类似分子量的市售胺封端聚乙二醇 (HO-PEG-NH _{2 ) 进行后功能化。}在目前的工作中，对这些涂层的化学稳定性、蛋白质污染特性和细胞污染特性进行了比较。lPG-b-OA ₁₁-功能化涂层在磷酸盐缓冲盐水 (PBS) 和十二烷基硫酸钠 (SDS) 溶液中均显示出较高的化学稳定性，并且与裸露的二氧化钛基材。_{此外，当将 lPG-b-OA 11}系统与裸露的二氧化钛进行比较时，人脐静脉内皮细胞 (HUVEC) 的增殖减少了 85% 。此外，当将 lPG-b-OA ₁₁系统与组织培养聚苯乙烯进行比较时，观察到减少了 94%。

更新日期：2019-11-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南