Phosphorus pentoxide and DMAP are used for amide bond formation from carboxylic acids and amines. Dipeptides and amides have been synthesized using this reagent in 42-77% yields and >99% ees. The protocol is attractive as it occurs at ambient temperature, the formation of organic by-products is minimal and the reagent can be readily quenched using water. Furthermore, excellent enantioselectivities are observed without the use of harsh triazole based additives.

中文翻译：

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五氧化二磷可形成酰胺和肽键，副产物最少

五氧化二磷和DMAP用于由羧酸和胺形成酰胺键。使用该试剂已合成了二肽和酰胺，产率为42-77％，ee大于99％。该方案具有吸引力，因为它在环境温度下发生，有机副产物的形成极少，并且试剂可以很容易地用水淬灭。此外，在不使用苛刻的三唑基添加剂的情况下，观察到优异的对映选择性。