Mn–Porphyrin-Based Metal–Organic Framework with High Longitudinal Relaxivity for Magnetic Resonance Imaging Guidance and Oxygen Self-Supplementing Photodynamic Therapy,ACS Applied Materials & Interfaces

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Mn–Porphyrin-Based Metal–Organic Framework with High Longitudinal Relaxivity for Magnetic Resonance Imaging Guidance and Oxygen Self-Supplementing Photodynamic Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-10-29 , DOI: 10.1021/acsami.9b15083
Meie He ₁ , Yanan Chen ₁ , Cheng Tao ₁ , Qingqing Tian ₁ , Lu An ₁ , Jiaomin Lin ₁ , Qiwei Tian ₁ , Hong Yang ₁ , Shiping Yang ₁

Affiliation

A nanoplatform for magnetic resonance imaging guidance and oxygen self-supplementing photodynamic therapy (PDT) was constructed on the basis of a porous metal–organic framework (PCN-222(Mn)), which was built by simple Mn–porphyrin ligands and biocompatible Zr⁴⁺ ions. Because of the good dispersibility of Mn³⁺ in the open framework and the high water affinity of the channel, PCN-222(Mn) exhibits a high longitudinal relaxivity of ∼35.3 mM^–1 s^–1 (1.0 T). In addition, it shows good catalytic activity for the conversion of endogenous hydrogen peroxide into oxygen, thereby improving tumor hypoxia during photodynamic therapy. The intravenous injection of PCN-222(Mn) into tumor-bearing mice mode provided good T₁-weighted contrast of the tumor site and effectively inhibited tumor growth upon a single-laser irradiation. The findings provide insights for the development of multifunctional theranostic nanoplatforms based on simple components.

中文翻译：

锰-卟啉基金属-有机骨架具有高的纵向弛豫性，可用于磁共振成像指导和氧自补光动力疗法

在多孔金属-有机骨架（PCN-222（Mn））的基础上，构建了用于磁共振成像指导和氧自补光动力疗法（PDT）的纳米平台，该平台由简单的Mn-卟啉配体和生物相容性Zr构成⁴⁺离子。由于Mn ³⁺在开放框架中的良好分散性和通道的高水亲合力，PCN-222（Mn）表现出约35.3 mM ^–1 s ^–1（1.0 T）的高纵向松弛度。此外，它显示出良好的催化活性，可将内源性过氧化氢转化为氧气，从而改善光动力疗法中的肿瘤缺氧。荷瘤小鼠静脉注射PCN-222（Mn）可提供良好的T ₁肿瘤部位的加权对比，并在单激光照射下有效抑制了肿瘤的生长。该发现为基于简单组分的多功能治疗药物纳米平台的开发提供了见识。

更新日期：2019-10-29

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