Synthesis ( IF 2.2 ) Pub Date : 2019-10-21 , DOI: 10.1055/s-0039-1690694 Bouthayna Zilate , Christian Fischer , Lukas Schneider , Christof Sparr 1
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Abstract
The continuous development of photocatalytic methods incentivizes the design of organic catalysts to complement the frequently used and precious polypyridyl transition metal systems. Herein, a scalable synthesis of suitable acridinium dyes and their application in photoredox deuterations are described. The acridinium catalysts, prepared on multi-gram scale, allowed the deuteration of a pharmaceutically relevant scaffold in high yield and selectivity under mild conditions.
The continuous development of photocatalytic methods incentivizes the design of organic catalysts to complement the frequently used and precious polypyridyl transition metal systems. Herein, a scalable synthesis of suitable acridinium dyes and their application in photoredox deuterations are described. The acridinium catalysts, prepared on multi-gram scale, allowed the deuteration of a pharmaceutically relevant scaffold in high yield and selectivity under mild conditions.
中文翻译：
用于光氧化还原氘的A啶催化剂的可扩展合成
抽象的
光催化方法的不断发展激发了有机催化剂的设计，以补充常用和珍贵的聚吡啶基过渡金属体系。本文描述了合适的suitable啶染料的可扩展合成及其在光氧化还原氘中的应用。以克为单位制备的cri啶鎓催化剂可以在温和条件下以高收率和选择性对药学相关的支架进行氘化。
光催化方法的不断发展激发了有机催化剂的设计，以补充常用和珍贵的聚吡啶基过渡金属体系。本文描述了合适的suitable啶染料的可扩展合成及其在光氧化还原氘中的应用。以克为单位制备的cri啶鎓催化剂可以在温和条件下以高收率和选择性对药学相关的支架进行氘化。
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