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Development of a new ratiometric probe with near-infrared fluorescence and a large Stokes shift for detection of gasotransmitter CO in living cells.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2019-10-20 , DOI: 10.1016/j.saa.2019.117657 Enbo Zhou 1 , Shengyi Gong 1 , Jiaxin Hong 1 , Guoqiang Feng 1
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2019-10-20 , DOI: 10.1016/j.saa.2019.117657 Enbo Zhou 1 , Shengyi Gong 1 , Jiaxin Hong 1 , Guoqiang Feng 1
Affiliation
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A near-infrared (NIR) ratiometric fluorescent probe, NIR-Ratio-CO, was developed for rapid detection of carbon monoxide (CO) in both solution and living cells through the strategy of Pd0-mediated Tsuji-Trost reaction. This probe shows a rapid, highly specific and sensitive detection process for CO, accompanied by colorimetric and distinct ratiometric fluorescence changes at 655 and 592 nm with a large Stokes shift up to 195 nm. The detection limit for CO was measured to be about 61 nM by the fluorescence method. In addition, this probe was successfully applied for ratiometric imaging of both exogenous and endogenous CO in living cells, indicating that it can be used as a novel tool for ratiometric fluorescent detection of CO in living systems.
中文翻译：
开发了一种新型的具有近红外荧光和大斯托克斯位移的比例式探针，用于检测活细胞中的气体递质CO。
开发了一种近红外（NIR）比例荧光探针NIR-Ratio-CO，用于通过Pd0介导的Tsuji-Trost反应策略快速检测溶液和活细胞中的一氧化碳（CO）。该探针显示了一种快速，高度特异性和灵敏的CO检测过程，并在655和592 nm处进行了比色和明显的比例荧光变化，斯托克斯位移高达195 nm。通过荧光法测得的CO的检出限为约61nM。此外，该探针已成功用于活细胞中外源性和内源性CO的比例成像，表明它可以用作活体系统中CO的比例荧光检测的新型工具。
更新日期：2019-10-20
中文翻译：
开发了一种新型的具有近红外荧光和大斯托克斯位移的比例式探针，用于检测活细胞中的气体递质CO。
开发了一种近红外（NIR）比例荧光探针NIR-Ratio-CO，用于通过Pd0介导的Tsuji-Trost反应策略快速检测溶液和活细胞中的一氧化碳（CO）。该探针显示了一种快速，高度特异性和灵敏的CO检测过程，并在655和592 nm处进行了比色和明显的比例荧光变化，斯托克斯位移高达195 nm。通过荧光法测得的CO的检出限为约61nM。此外，该探针已成功用于活细胞中外源性和内源性CO的比例成像，表明它可以用作活体系统中CO的比例荧光检测的新型工具。
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