Cover Feature: Cyclodextrin‐Sandwiched Hexaphyrin Hybrids: Side‐to‐Side Cavity Coupling Switched by a Temperature‐ and Redox‐Responsive Central Device (Chem. Eur. J. 22/2018),Chemistry - A European Journal

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Cover Feature: Cyclodextrin‐Sandwiched Hexaphyrin Hybrids: Side‐to‐Side Cavity Coupling Switched by a Temperature‐ and Redox‐Responsive Central Device (Chem. Eur. J. 22/2018)
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-03-07 , DOI: 10.1002/chem.201800590
Mickaël Ménand ₁ , Matthieu Sollogoub ₁ , Bernard Boitrel ₂ , Stéphane Le Gac ₂

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Targeting adaptive receptors for allosteric enzyme mimicry, sandwich hybrids composed of a hexaphyrin capped by two cyclodextrins have been synthesized. The hexaphyrin behaves as a dual‐responsive device which couples the two cyclodextrins in a switchable manner through redox ([anti]aromaticity) and thermal (conformation) control. Conformational isomerization of the central unit tunes the access to the twin confined spaces being either locked or unlocked for both aromatic and antiaromatic states. This four‐state system controlled by two orthogonal switches offers an interesting playground for further allosteric regulation. More information can be found in the Full Paper by M. Ménand, S. Le Gac et al. on page 5804.

中文翻译：

封面功能：环糊精夹心的六氟卟啉杂化物：通过温度和氧化还原敏感的中央设备切换的侧腔耦合（Chem。Eur。J. 22/2018）

针对变构酶拟态的适应性受体，已经合成了由两个环糊精封端的六氢卟啉组成的夹心杂种。六卟啉具有双重响应功能，可通过氧化还原（[反芳香性]）和热（构象）控制以可切换的方式偶联两个环糊精。中心单元的构象异构化调整了进入两个密闭空间的通道，该空间对于芳香族和反芳香族状态都处于锁定状态或未锁定状态。这个由两个正交开关控制的四态系统为进一步的变构调节提供了一个有趣的场所。可以在M.Ménand，S. Le Gac等人的论文全文中找到更多信息。在5804页上。

更新日期：2018-03-07

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