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Functionalized Metal–Organic Framework UiO-66-NH-BQB for Selective Detection of Hydrogen Sulfide and Cysteine
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-10-30 , DOI: 10.1021/acsami.9b16529 Huazheng Yu 1 , Chuanyao Liu 1 , Yanhong Li 1 , Aisheng Huang 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-10-30 , DOI: 10.1021/acsami.9b16529 Huazheng Yu 1 , Chuanyao Liu 1 , Yanhong Li 1 , Aisheng Huang 1
Affiliation
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Hydrogen sulfide (H2S) is an important signaling molecule related to many diseases. Thus, H2S has a great impact on the pathological and physiological processes in biological systems. Cysteine (l-Cys) is a building block for proteins and important metabolites. To understand their roles in the physiological metabolic procedures, the measurement of the H2S level and identifying cysteine in the biological system is significant. In this study, through the functionalization of UiO-66-NH2 by 4-(2,2-dicyanoethenyl)benzoic acid (BQB), a novel UiO-66-NH-BQB is successfully synthesized and used as a fluorescence probe to recognize and detect H2S and l-Cys. The fluorescence signals of the probe are enhanced great when it is exposed to H2S or cysteine molecules; thus, it is able to determine quantificationally the H2S concentration in an aqueous solution. The detection limitation of the UiO-66-NH-BQB to H2S concentration is found to be as low as 1.74 μM. The developed fluorescent probe based on UiO-66-NH-BQB displays a high selectivity and excellent biocompatibility, which is very promising for recognition and sensing of biothiols in organisms.
中文翻译：
功能性金属有机框架UiO-66-NH-BQB用于选择性检测硫化氢和半胱氨酸
硫化氢（H 2 S）是与许多疾病相关的重要信号分子。因此，H 2 S对生物系统中的病理和生理过程具有很大的影响。半胱氨酸（l- Cys）是蛋白质和重要代谢物的构建基块。为了了解它们在生理代谢过程中的作用，在生物系统中测量H 2 S水平和鉴定半胱氨酸具有重要意义。在这项研究中，通过4-（2,2-二氰基乙烯基）苯甲酸（BQB）对UiO-66-NH 2的功能化，成功合成了一种新型UiO-66-NH-BQB，并将其用作荧光探针来识别并检测H 2 S和l-是的。当探针暴露于H 2 S或半胱氨酸分子时，其荧光信号会大大增强。因此，能够定量测定水溶液中的H 2 S浓度。发现UiO-66-NH-BQB对H 2 S浓度的检测限低至1.74μM。基于UiO-66-NH-BQB的荧光探针显示出高选择性和出色的生物相容性，对于识别和感测生物体内的生物硫醇非常有前途。
更新日期：2019-10-30
中文翻译：
功能性金属有机框架UiO-66-NH-BQB用于选择性检测硫化氢和半胱氨酸
硫化氢（H 2 S）是与许多疾病相关的重要信号分子。因此，H 2 S对生物系统中的病理和生理过程具有很大的影响。半胱氨酸（l- Cys）是蛋白质和重要代谢物的构建基块。为了了解它们在生理代谢过程中的作用，在生物系统中测量H 2 S水平和鉴定半胱氨酸具有重要意义。在这项研究中，通过4-（2,2-二氰基乙烯基）苯甲酸（BQB）对UiO-66-NH 2的功能化，成功合成了一种新型UiO-66-NH-BQB，并将其用作荧光探针来识别并检测H 2 S和l-是的。当探针暴露于H 2 S或半胱氨酸分子时，其荧光信号会大大增强。因此，能够定量测定水溶液中的H 2 S浓度。发现UiO-66-NH-BQB对H 2 S浓度的检测限低至1.74μM。基于UiO-66-NH-BQB的荧光探针显示出高选择性和出色的生物相容性，对于识别和感测生物体内的生物硫醇非常有前途。
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