Decoupling of brain function from structure reveals regional behavioral specialization in humans.,Nature Communications

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Decoupling of brain function from structure reveals regional behavioral specialization in humans.
Nature Communications ( IF 14.7 ) Pub Date : 2019-10-18 , DOI: 10.1038/s41467-019-12765-7
Maria Giulia Preti _{1,

2} , Dimitri Van De Ville _{1,

2}

Affiliation

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected areas can be expected higher. However, the degree to which brain function is bound by the underlying wiring diagram remains a complex question that has been only partially answered. Here, we introduce the structural-decoupling index to quantify the coupling strength between structure and function, and we reveal a macroscale gradient from brain regions more strongly coupled, to regions more strongly decoupled, than expected by realistic surrogate data. This gradient spans behavioral domains from lower-level sensory function to high-level cognitive ones and shows for the first time that the strength of structure-function coupling is spatially varying in line with evidence derived from other modalities, such as functional connectivity, gene expression, microstructural properties and temporal hierarchy.

中文翻译：

脑功能与结构的脱钩揭示了人类的区域行为专长。

大脑是通过结构途径相互连接的神经元种群的集合。脑活动在该底物上表达并受其限制。因此，可以期望在直接连接的区域中功能信号之间的统计依赖性更高。但是，大脑功能受底层布线图约束的程度仍然是一个复杂的问题，仅得到部分回答。在这里，我们引入结构去耦指数来量化结构与功能之间的耦合强度，并且我们揭示了从比实际替代数据预期更强耦合的脑区域到更强解耦的区域的宏观梯度。

更新日期：2019-10-19

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