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Diiron Hexacarbonyl Complex Induces Site-Specific Release of Carbon Monoxide in Cancer Cells Triggered by Endogenous Glutathione
ACS Omega ( IF 3.7 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acsomega.8b00052 Cunji Gao 1 , Xiaohua Liang 1 , Zhengxi Guo 1 , Bang-Ping Jiang 1 , Xiaoming Liu 2 , Xing-Can Shen 1
ACS Omega ( IF 3.7 ) Pub Date : 2018-03-06 00:00:00 , DOI: 10.1021/acsomega.8b00052 Cunji Gao 1 , Xiaohua Liang 1 , Zhengxi Guo 1 , Bang-Ping Jiang 1 , Xiaoming Liu 2 , Xing-Can Shen 1
Affiliation
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In this study, we have evaluated a water-soluble, nontarget reagent and a carrier-free diiron hexacarbonyl complex, [Fe2{μ-SCH2CH(OH)CH2(OH)}2(CO)6] (TG-FeCORM), that can induce the site-specific release of carbon monoxide (CO) in cancer cells triggered by endogenous glutathione (GSH). The releasing rate of CO was dependent on the amount of endogenous GSH. Being the amount of endogenous GSH higher in cancer cells than in normal cells, the CO-releasing rate resulted faster in cancer cells. Moreover, the anti-inflammatory properties related to the intracellular CO release of TG-FeCORM were also confirmed in the living HeLa cells.
中文翻译：
Diiron六羰基配合物诱导内源性谷胱甘肽触发的癌细胞中一氧化碳的定点释放
在这项研究中，我们评价了水溶性，非靶试剂和无载体的六羰基二铁配合物[铁2 {μ-SCH 2 CH（OH）CH 2（OH）} 2（CO）6 ]（TG- FeCORM）可以诱导内源性谷胱甘肽（GSH）触发的癌细胞中一氧化碳（CO）的定点释放。CO的释放速率取决于内源性GSH的量。由于癌细胞中的内源性GSH含量高于正常细胞，因此CO释放速率在癌细胞中产生得更快。此外，在活的HeLa细胞中也证实了与TG-FeCORM的细胞内CO释放有关的抗炎特性。
更新日期：2018-03-06
中文翻译：
Diiron六羰基配合物诱导内源性谷胱甘肽触发的癌细胞中一氧化碳的定点释放
在这项研究中，我们评价了水溶性，非靶试剂和无载体的六羰基二铁配合物[铁2 {μ-SCH 2 CH（OH）CH 2（OH）} 2（CO）6 ]（TG- FeCORM）可以诱导内源性谷胱甘肽（GSH）触发的癌细胞中一氧化碳（CO）的定点释放。CO的释放速率取决于内源性GSH的量。由于癌细胞中的内源性GSH含量高于正常细胞，因此CO释放速率在癌细胞中产生得更快。此外，在活的HeLa细胞中也证实了与TG-FeCORM的细胞内CO释放有关的抗炎特性。
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