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The clinical potential of circulating microRNAs in obesity.
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2019-10-14 , DOI: 10.1038/s41574-019-0260-0 Chenbo Ji 1 , Xirong Guo 1, 2
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2019-10-14 , DOI: 10.1038/s41574-019-0260-0 Chenbo Ji 1 , Xirong Guo 1, 2
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Obesity is a complex condition that is characterized by excessive fat accumulation, which can lead to the development of metabolic disorders, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular diseases. Evidence is accumulating that circulating microRNAs (miRNAs) act as a new class of endocrine factor. These miRNAs are released by many types of tissue, including adipose tissues. miRNAs might serve as endocrine and paracrine messengers that facilitate communication between donor cells and tissues with receptor cells or target tissues, thereby potentially having important roles in metabolic organ crosstalk. Moreover, many miRNAs are closely associated with the differentiation of adipocytes and are dysregulated in obesity. As such, circulating miRNAs are attractive potential biomarkers and hold promise for the development of miRNA-based therapeutics (such as miRNA mimetics, anti-miRNA oligonucleotides and exosomes loaded with miRNA) for obesity and related disorders. Here we review the latest research progress on the roles of circulating miRNAs in metabolic organ crosstalk. In addition, we discuss the clinical potential of circulating miRNAs as feasible biomarkers for the assessment of future risk of metabolic disorders and as therapeutic targets in obesity and related diseases.
中文翻译：
肥胖中循环microRNA的临床潜力。
肥胖症是一种复杂的疾病，其特征在于过多的脂肪积聚，这会导致代谢异常的发生，例如2型糖尿病，非酒精性脂肪肝疾病和心血管疾病。越来越多的证据表明循环微RNA（miRNA）可以作为一类新的内分泌因子。这些miRNA由多种类型的组织（包括脂肪组织）释放。miRNA可以充当内分泌和旁分泌信使，促进供体细胞和组织与受体细胞或靶组织之间的通讯，从而潜在地在代谢器官串扰中发挥重要作用。此外，许多miRNA与脂肪细胞的分化密切相关，并且在肥胖症中失调。因此，循环中的miRNA是诱人的潜在生物标志物，并有望为肥胖症和相关疾病开发基于miRNA的疗法（例如miRNA模拟物，抗miRNA寡核苷酸和装载miRNA的外来体）。在这里，我们回顾了循环miRNA在代谢器官串扰中的作用的最新研究进展。此外，我们讨论了循环miRNA的临床潜力，将其作为可行的生物标记物，用于评估未来代谢性疾病的风险以及作为肥胖症和相关疾病的治疗靶标。
更新日期：2019-10-15
中文翻译：
肥胖中循环microRNA的临床潜力。
肥胖症是一种复杂的疾病，其特征在于过多的脂肪积聚，这会导致代谢异常的发生，例如2型糖尿病，非酒精性脂肪肝疾病和心血管疾病。越来越多的证据表明循环微RNA（miRNA）可以作为一类新的内分泌因子。这些miRNA由多种类型的组织（包括脂肪组织）释放。miRNA可以充当内分泌和旁分泌信使，促进供体细胞和组织与受体细胞或靶组织之间的通讯，从而潜在地在代谢器官串扰中发挥重要作用。此外，许多miRNA与脂肪细胞的分化密切相关，并且在肥胖症中失调。因此，循环中的miRNA是诱人的潜在生物标志物，并有望为肥胖症和相关疾病开发基于miRNA的疗法（例如miRNA模拟物，抗miRNA寡核苷酸和装载miRNA的外来体）。在这里，我们回顾了循环miRNA在代谢器官串扰中的作用的最新研究进展。此外，我们讨论了循环miRNA的临床潜力，将其作为可行的生物标记物，用于评估未来代谢性疾病的风险以及作为肥胖症和相关疾病的治疗靶标。
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