Synthesizing artificial polymers with precise sequence structures, such as their biological analogues, is a serious challenge and of great importance in polymer science. Recently, step-growth polymerization and chain growth polymerization have been the main synthesis methods for preparing artificial sequence-regulated polymers. However, it is difficult to obtain sequence-controlled polymers with sufficient molecular diversity via step-growth polymerization; on the other hand, chain-growth polymerization generally requires laborious repetitive monomer feeding. In this focus review, the sequential multicomponent reactions for preparing periodic sequence-controlled polymers with sufficient molecular diversity and complexity and the interconvertible hybrid copolymerizations producing hybrid multiblock copolymers rapidly in one pot are highlighted. We have developed sequential multicomponent reaction and interconvertible hybrid copolymerization methods to prepare sequence-controlled polymers. The sequential multicomponent reaction combines more than two different multicomponent reactions in one pot to prepare periodic sequence˗controlled polymers with sufficient molecular diversity. The interconvertible hybrid copolymerization method uses trithiocarbonate compounds to combine radical polymerization of vinyl monomers and anionic ring-opening polymerization of thiirane monomers, resulting in hybrid multiblock sequence-regulated polymers.

中文翻译：

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通过顺序多组分反应和相互转化的杂化共聚合成顺序控制的聚合物

合成具有精确序列结构的人造聚合物，例如它们的生物类似物，是一项严峻的挑战，并且在聚合物科学中具有重要意义。近年来，逐步增长聚合和链增长聚合已成为制备人工序列调节聚合物的主要合成方法。然而，通过逐步增长聚合很难获得具有足够分子多样性的序列控制聚合物；另一方面，链增长聚合通常需要费力的重复单体进料。在这篇焦点综述中，重点介绍了用于制备具有足够分子多样性和复杂性的周期性序列控制聚合物的顺序多组分反应，以及在一锅中快速产生杂化多嵌段共聚物的互转化杂化共聚反应。我们开发了顺序多组分反应和互转化杂化共聚方法来制备顺序控制的聚合物。顺序多组分反应在一锅中结合了两种以上不同的多组分反应，以制备具有足够分子多样性的周期性序列控制聚合物。可相互转化的杂化共聚方法使用三硫代碳酸酯化合物将乙烯基单体的自由基聚合和硫杂环丁烷单体的阴离子开环聚合相结合，产生杂化多嵌段序列调节聚合物。顺序多组分反应在一锅中结合了两种以上不同的多组分反应，以制备具有足够分子多样性的周期性序列控制聚合物。可相互转化的杂化共聚方法使用三硫代碳酸酯化合物将乙烯基单体的自由基聚合和硫杂环丁烷单体的阴离子开环聚合相结合，产生杂化多嵌段序列调节聚合物。顺序多组分反应在一锅中结合了两种以上不同的多组分反应，以制备具有足够分子多样性的周期性序列控制聚合物。可相互转化的杂化共聚方法使用三硫代碳酸酯化合物将乙烯基单体的自由基聚合和硫杂环丁烷单体的阴离子开环聚合相结合，产生杂化多嵌段序列调节聚合物。