Recent Progress in Ferroptosis Inducers for Cancer Therapy.,Advanced Materials

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Recent Progress in Ferroptosis Inducers for Cancer Therapy.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-10-08 , DOI: 10.1002/adma.201904197
Chen Liang ₁ , Xinglin Zhang ₂ , Mengsu Yang _{1,

3} , Xiaochen Dong _{2,

4}

Affiliation

Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis-inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.

中文翻译：

铁线虫病诱导剂在癌症治疗中的最新进展。

Ferroptosis是调节细胞死亡的新发现形式，是新陈代谢，氧化还原生物学和人类健康之间的纽带。越来越多的证据表明，在治疗癌症中，特别是在消除对传统疗法有抵抗力的侵袭性恶性肿瘤方面，有可能引发促发性铁锈病。近来，已经进行了大量的工作来设计和开发基于促肥大症的抗癌药物。提出了在化学，材料科学和癌症生物学的交叉领域中促发铁蛋白病的药物的最新进展。首先总结了肥大症的基础，以突出触发肥大症用于癌症治疗的可行性和特征。然后提出了有关促肥大病诱发剂（包括小分子和纳米材料）的文献综述，以描述其设计，作用机制和抗癌应用。最后，重点介绍了有关促肥生病诱导剂研究的一些注意事项，然后讨论了这个新兴领域的挑战和未来的发展方向。

更新日期：2019-12-18

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