Engineered Zinc Titanate Coatings on the Titanium Surface with Enhanced Antitumor Properties and Biocompatibility,ACS Biomaterials Science & Engineering

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Engineered Zinc Titanate Coatings on the Titanium Surface with Enhanced Antitumor Properties and Biocompatibility
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-10-17 , DOI: 10.1021/acsbiomaterials.9b00841
Meng Zhang ₁ , Zheni Gong ₁ , Jiting Zhang ₁ , Haoyan Cheng ₂ , Jisheng Chen ₁ , Yan Zeng ₃ , Zhihong Zhu ₁ , Ying Wan ₄

Affiliation

Surgical treatment of osteosarcoma is usually difficult to radically eliminate cancer cells, and it will concomitantly result in bone defects with varied sizes. To prevent tumor recurrence and reconstruction of the bone defect, there is a pressing need to develop suitable implants that have anticancer capability while promoting the regeneration of bone tissues. Here, we first report the design and fabrication of titanium-based implants engineered with a series of alveolate double-layered zinc titanate nanogridding coatings (NG-Zn0.01, NG-Zn0.05, NG-Zn0.10, NG-Zn0.15, and NG-Zn0.20). Biological assays in vitro indicate that the NG-Zn samples with long-lasting Zn ion release are able to efficiently inhibit the proliferation of osteosarcoma cells (MG63) in a dose-dependent manner, trigger cell cycle arrest, and induce cell apoptosis by the activation of the mitochondria pathway. More importantly, the optimized NG-Zn0.15 implant shows significant tumor inhibitory and proapoptotic abilities based on the assessment using a nude mouse osteosarcoma xenograft model. Additionally, the zinc titanate coatings with the nanogridding structure and appropriate Zn content exhibit favorable effects on osteoblast (MC3T3-E1) growth in vitro. It is verified that the NG-Zn0.15 implant is the optimal one with high efficiency against tumors and good biocompatibility, and it has promising potential in the surgical treatment of osteosarcoma.

中文翻译：

具有增强的抗肿瘤特性和生物相容性的钛表面工程钛酸锌涂层

骨肉瘤的外科治疗通常难以从根本上消除癌细胞，并且随之而来的是大小不一的骨缺损。为了防止肿瘤复发和骨缺损的重建，迫切需要开发合适的具有抗癌能力同时促进骨组织再生的植入物。在这里，我们首先报告设计和制造一系列一系列的肺泡双层钛酸锌纳米网格涂层（NG-Zn0.01，NG-Zn0.05，NG-Zn0.10，NG-Zn0）的钛基植入物的设计和制造。 15和NG-Zn0.20）。体外生物学分析表明，具有持久锌离子释放的NG-Zn样品能够以剂量依赖的方式有效抑制骨肉瘤细胞（MG63）的增殖，触发细胞周期停滞，并通过激活线粒体途径诱导细胞凋亡。更重要的是，基于裸鼠骨肉瘤异种移植模型的评估，优化的NG-Zn0.15植入物显示出显着的肿瘤抑制和促凋亡能力。此外，具有纳米网格结构和适当的Zn含量的钛酸锌涂层对体外成骨细胞（MC3T3-E1）的生长表现出有利的影响。事实证明，NG-Zn0.15植入物是抗肿瘤高效，生物相容性良好的最佳植入物，在骨肉瘤的手术治疗中具有广阔的应用前景。具有纳米网格结构和适当锌含量的钛酸锌涂层对体外成骨细胞（MC3T3-E1）的生长表现出有利的影响。事实证明，NG-Zn0.15植入物是抗肿瘤高效，生物相容性良好的最佳植入物，在骨肉瘤的手术治疗中具有广阔的应用前景。具有纳米网格结构和适当锌含量的钛酸锌涂层对体外成骨细胞（MC3T3-E1）的生长表现出有利的影响。事实证明，NG-Zn0.15植入物是抗肿瘤高效，生物相容性良好的最佳植入物，在骨肉瘤的手术治疗中具有广阔的应用前景。

更新日期：2019-10-17

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