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Biphasic Injectable Bone Cement with Fe3O4/GO Nanocomposites for the Minimally Invasive Treatment of Tumor-Induced Bone Destruction
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-10-17 , DOI: 10.1021/acsbiomaterials.9b00472 Feifei Yan 1 , Zhibo Liu 1 , Tie Zhang 2 , Qi Zhang 2 , Yan Chen 1 , Yuanlong Xie 1 , Jun Lei 1 , Lin Cai 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2019-10-17 , DOI: 10.1021/acsbiomaterials.9b00472 Feifei Yan 1 , Zhibo Liu 1 , Tie Zhang 2 , Qi Zhang 2 , Yan Chen 1 , Yuanlong Xie 1 , Jun Lei 1 , Lin Cai 1
Affiliation
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Minimally invasive surgery will be gradually applied to the surgical treatment of bone tumors. One of the difficulties in the minimally invasive treatment of bone tumors is the lack of injectable materials that can be used to treat tumor-induced bone defects. Therefore, it is imperative to develop an injectable bone filler that can not only be injected into the defect site by minimally invasive methods to provide strong support and repair bone tissue but also inactivate residual tumor cells around the defect. To achieve this aim, in our study, for the first time, we doped Fe3O4/graphene oxide (GO) nanocomposites into α-tricalcium phosphate (α-TCP)/calcium sulfate (CS) biphasic bone cement to prepare an injectable magnetic bone cement (α-TCP/CS/Fe3O4/GO, αCFG), which can be applied in bone tumor minimally invasive surgery and fit ideally even if the area is irregular. The magnetothermal performance of the αCFG bone cement could be well adjusted by altering the content of Fe3O4/GO nanocomposites and the magnetic field parameters, but a 10 wt % Fe3O4/GO content formed the most stable bone cement with excellent magnetothermal performance. The αCFG bone cement not only promotes bone regeneration but also exhibits enhanced tumor treatment effects. Such multifunctional bone cement could provide a promising clinical strategy for the minimally invasive treatment of tumor-induced bone destruction.
中文翻译：
Fe 3 O 4 / GO纳米复合材料的双相可注射骨水泥对肿瘤引起的骨破坏的微创治疗
微创手术将逐渐应用于骨肿瘤的外科治疗。骨肿瘤的微创治疗的困难之一是缺乏可用于治疗肿瘤引起的骨缺损的可注射材料。因此，迫切需要开发一种可注射的骨填充物，其不仅可以通过微创方法注入到缺损部位，以提供强大的支持和修复骨组织，而且可以使缺损周围的残留肿瘤细胞失活。为了达到这个目的，在我们的研究中，我们第一次将Fe 3 O 4 /氧化石墨烯（GO）纳米复合物掺入了α-磷酸三钙（α-TCP）/硫酸钙（CS）双相骨水泥中，制备了可注射的磁性骨水泥（α-TCP/ CS / Fe 3 O4 / GO，αCFG），可用于骨肿瘤微创手术，即使区域不规则也可以理想地适合。通过改变Fe 3 O 4 / GO纳米复合材料的含量和磁场参数可以很好地调节αCFG骨水泥的磁热性能，但是10 wt％的Fe 3 O 4 / GO含量是最稳定的骨水泥，具有优异的磁化性能。磁热性能。αCFG骨水泥不仅促进骨骼再生，而且还具有增强的肿瘤治疗效果。这种多功能骨水泥可以为肿瘤诱导的骨破坏的微创治疗提供有前途的临床策略。
更新日期：2019-10-17
中文翻译：
Fe 3 O 4 / GO纳米复合材料的双相可注射骨水泥对肿瘤引起的骨破坏的微创治疗
微创手术将逐渐应用于骨肿瘤的外科治疗。骨肿瘤的微创治疗的困难之一是缺乏可用于治疗肿瘤引起的骨缺损的可注射材料。因此，迫切需要开发一种可注射的骨填充物，其不仅可以通过微创方法注入到缺损部位，以提供强大的支持和修复骨组织，而且可以使缺损周围的残留肿瘤细胞失活。为了达到这个目的，在我们的研究中，我们第一次将Fe 3 O 4 /氧化石墨烯（GO）纳米复合物掺入了α-磷酸三钙（α-TCP）/硫酸钙（CS）双相骨水泥中，制备了可注射的磁性骨水泥（α-TCP/ CS / Fe 3 O4 / GO，αCFG），可用于骨肿瘤微创手术，即使区域不规则也可以理想地适合。通过改变Fe 3 O 4 / GO纳米复合材料的含量和磁场参数可以很好地调节αCFG骨水泥的磁热性能，但是10 wt％的Fe 3 O 4 / GO含量是最稳定的骨水泥，具有优异的磁化性能。磁热性能。αCFG骨水泥不仅促进骨骼再生，而且还具有增强的肿瘤治疗效果。这种多功能骨水泥可以为肿瘤诱导的骨破坏的微创治疗提供有前途的临床策略。
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