Wearable sensors are becoming increasingly more available in Parkinson’s disease and are used to measure motor function. Whether non-motor symptoms (NMS) can also be measured with these wearable sensors remains unclear. We therefore performed a retrospective, exploratory, analysis of 108 patients with a diagnosis of idiopathic Parkinson’s disease enroled in the Non-motor Longitudinal International Study (UKCRN No. 10084) at King’s College Hospital, London, to determine the association between the range and nature of NMS and an accelerometer-based outcome measure of bradykinesia (BKS) and dyskinesia (DKS). NMS were assessed by the validated NMS Scale, and included, e.g., cognition, mood and sleep, and gastrointestinal, urinary and sexual problems. Multiple linear regression modelling was used to identify NMS associated with BKS and DKS. We found that BKS was associated with domains 6 (gastrointestinal tract; p = 0.006) and 8 (sexual function; p = 0.003) of the NMS scale. DKS was associated with domains 3 (mood/cognition; p = 0.016), 4 (perceptual problems; p = 0.025), 6 (gastrointestinal tract; p = 0.029) and 9 (miscellaneous, p = 0.003). In the separate domains, constipation was significantly associated with BKS. Delusions, dysphagia, hyposmia, weight change and hyperhidrosis were identified as significantly associated with DKS. None of the NMSS domains were associated with disease duration (p ≥ 0.08). In conclusion, measures of BKS and DKS were mainly associated with gastrointestinal problems, independent of disease duration, showing the potential for wearable devices to pick up on these symptoms. These exploratory results deserve further exploration, and more research on this topic in the form of comprehensive large-scale studies is needed.

可穿戴式传感器在帕金森氏病中变得越来越可用，并用于测量运动功能。这些可穿戴式传感器是否也可以测量非运动症状（NMS），目前尚不清楚。因此，我们对伦敦金斯学院医院的非运动纵向国际研究（UKCRN No. 10084）中纳入的108例诊断为特发性帕金森病的患者进行了回顾性，探索性分析，以确定范围与自然之间的关联NMS以及基于运动计的运动迟缓（BKS）和运动障碍（DKS）的结果测量。NMS通过有效的NMS量表进行评估，包括认知，情绪和睡眠以及胃肠道，泌尿和性问题。多元线性回归模型用于识别与BKS和DKS相关的NMS。p  = 0.006）和 NMS量表的8（性功能；p = 0.003）。DKS与域3（情绪/认知; p  = 0.016），4（知觉问题; p  = 0.025），6（胃肠道; p  = 0.029）和9（其他，p  = 0.003）相关。在单独的领域中，便秘与BKS显着相关。妄想，吞咽困难，体力减退，体重变化和多汗症被确定与DKS显着相关。没有NMSS域与疾病持续时间相关（p ≥0.08）。总之，BKS和DKS的测量主要与胃肠道问题有关，与疾病持续时间无关，这表明可穿戴设备有可能吸收这些症状。这些探索性的结果值得进一步探索，并且需要以大规模综合研究的形式对这个主题进行更多的研究。