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Probing the Intercalation of Noscapine from Sodium Dodecyl Sulfate Micelles to Calf Thymus Deoxyribose Nucleic Acid: A Mechanistic Approach
ACS Omega ( IF 3.7 ) Pub Date : 2019-09-17 , DOI: 10.1021/acsomega.9b01543 Neha Maurya 1 , Khalid Ahmed Alzahrani 2 , Rajan Patel 1
ACS Omega ( IF 3.7 ) Pub Date : 2019-09-17 , DOI: 10.1021/acsomega.9b01543 Neha Maurya 1 , Khalid Ahmed Alzahrani 2 , Rajan Patel 1
Affiliation
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Noscapine (NOS) is efficient in inhibiting cellular proliferation and induces apoptosis in nonsmall cell, lung, breast, lymphatic, and prostate cancers. The micelle-assisted drug delivery is a well-known phenomenon; however, the proper mechanism is still unclear. Therefore, in the present study, we have shown a mechanistic approach for the delivery of NOS from sodium dodecyl sulfate (SDS) micelles to calf thymus deoxyribose nucleic acid (ctDNA) base-pairs using various spectroscopic techniques. The absorption and emission spectroscopy results revealed that NOS interacts with the SDS micelle and resides in its hydrophobic core. Further, the intercalation of NOS from SDS micelles to ctDNA was also shown by these techniques. The anisotropy and quenching results further confirmed the relocation of NOS from SDS micelles to ctDNA. The CD analysis suggested that SDS micelles do not perturb the structure of ctDNA, which supported that SDS micelles can be used as a safe delivery vehicle for NOS. This work may be helpful for the invention of advanced micelle-based vehicles for the delivery of an anticancer drug to their specific target site.
中文翻译：
探索从十二烷基硫酸钠胶束向小牛胸腺脱氧核糖核酸中插入Noscapine的机理：
Noscapine（NOS）在非小细胞癌，肺癌，乳腺癌，淋巴癌和前列腺癌中均能有效抑制细胞增殖并诱导细胞凋亡。胶束辅助给药是一种众所周知的现象。但是，尚不清楚适当的机制。因此，在本研究中，我们显示了使用各种光谱技术将十二烷基硫酸钠硫酸钠（SDS）胶束中的NOS传递至小牛胸腺脱氧核糖核酸（ctDNA）碱基对的机械方法。吸收和发射光谱结果表明，NOS与SDS胶束相互作用，并位于其疏水核中。此外，这些技术还显示了从SDS胶束到ctDNA的NOS嵌入。各向异性和猝灭结果进一步证实了NOS从SDS胶束到ctDNA的重定位。CD分析表明，SDS胶束不会干扰ctDNA的结构，这支持SDS胶束可以用作NOS的安全递送载体。这项工作可能有助于发明先进的基于胶束的媒介物，以将抗癌药物递送至其特定的靶位。
更新日期：2019-10-01
中文翻译：
探索从十二烷基硫酸钠胶束向小牛胸腺脱氧核糖核酸中插入Noscapine的机理：
Noscapine（NOS）在非小细胞癌，肺癌，乳腺癌，淋巴癌和前列腺癌中均能有效抑制细胞增殖并诱导细胞凋亡。胶束辅助给药是一种众所周知的现象。但是，尚不清楚适当的机制。因此，在本研究中，我们显示了使用各种光谱技术将十二烷基硫酸钠硫酸钠（SDS）胶束中的NOS传递至小牛胸腺脱氧核糖核酸（ctDNA）碱基对的机械方法。吸收和发射光谱结果表明，NOS与SDS胶束相互作用，并位于其疏水核中。此外，这些技术还显示了从SDS胶束到ctDNA的NOS嵌入。各向异性和猝灭结果进一步证实了NOS从SDS胶束到ctDNA的重定位。CD分析表明，SDS胶束不会干扰ctDNA的结构，这支持SDS胶束可以用作NOS的安全递送载体。这项工作可能有助于发明先进的基于胶束的媒介物，以将抗癌药物递送至其特定的靶位。
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