A conjugative plasmid that augments virulence in Klebsiella pneumoniae.,Nature Microbiology

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A conjugative plasmid that augments virulence in Klebsiella pneumoniae.
Nature Microbiology ( IF 20.5 ) Pub Date : 2019-09-30 , DOI: 10.1038/s41564-019-0566-7
Xuemei Yang ₁ , Edward Wai-Chi Chan ₁ , Rong Zhang ₂ , Sheng Chen _{1,

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Affiliation

A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

中文翻译：

一种增强肺炎克雷伯菌毒力的结合质粒。

从临床水痘克雷伯菌菌株中回收了一个毒力编码质粒 p15WZ-82_Vir，它是由于将高毒力质粒 pLVPK 的 100 kb 片段整合到结合的 IncFIB 质粒中而形成的。这种质粒可以与耐碳青霉烯类克雷伯菌菌株结合，使它们能够同时表达碳青霉烯类耐药和高毒力相关的表型。与非结合 pLVPK 质粒不同，p15WZ-82_Vir 的出现可能会促进毒力编码元件在革兰氏阴性细菌病原体中的快速传播。

更新日期：2019-09-30

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