Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues.,Small

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Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues.
Small ( IF 13.0 ) Pub Date : 2019-09-26 , DOI: 10.1002/smll.201902838
Ruoxiao Xie ₁ , Wenchen Zheng ₁ , Liandi Guan ₁ , Yongjian Ai ₁ , Qionglin Liang ₁

Affiliation

Vascular systems are responsible for various physiological and pathological processes related to all organs in vivo, and the survival of engineered tissues for enough nutrient supply in vitro. Thus, biomimetic vascularization is highly needed for constructing both a biomimetic organ model and a reliable engineered tissue. However, many challenges remain in constructing vascularized tissues, requiring the combination of suitable biomaterials and engineering techniques. In this review, the advantages of hydrogels on building engineered vascularized tissues are discussed and recent engineering techniques for building perfusable microchannels in hydrogels are summarized, including micromolding, 3D printing, and microfluidic spinning. Furthermore, the applications of these perfusable hydrogels in manufacturing organ-on-a-chip devices and transplantable engineered tissues are highlighted. Finally, current challenges in recapitulating the complexity of native vascular systems are discussed and future development of vascularized tissues is prospected.

中文翻译：

具有可灌注微通道的水凝胶材料工程，用于构建血管化组织。

血管系统负责与体内所有器官相关的各种生理和病理过程，并负责工程组织的生存，以在体外提供足够的营养。因此，高度需要仿生血管化来构建仿生器官模型和可靠的工程组织。但是，在构建血管化组织方面仍然存在许多挑战，需要将合适的生物材料和工程技术结合起来。在这篇综述中，讨论了水凝胶在构建工程化的血管化组织方面的优势，并总结了在水凝胶中构建可灌注微通道的最新工程技术，包括微模塑，3D打印和微流体纺丝。此外，这些可灌输水凝胶在制造单片器官装置和可移植的工程组织中的应用得到了重点介绍。最后，讨论了概括天然血管系统复杂性的当前挑战，并展望了血管化组织的未来发展。

更新日期：2020-04-17

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