DAMP-sensing receptors in sterile inflammation and inflammatory diseases.,Nature Reviews Immunology

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DAMP-sensing receptors in sterile inflammation and inflammatory diseases.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-09-26 , DOI: 10.1038/s41577-019-0215-7
Tao Gong ₁ , Lei Liu ₁ , Wei Jiang ₁ , Rongbin Zhou _{1,

2}

Affiliation

The innate immune system has the capacity to detect 'non-self' molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern recognition receptors. In addition, an increasing number of endogenous host-derived molecules, termed damage-associated molecular patterns (DAMPs), have been found to be sensed by various innate immune receptors. The recognition of DAMPs, which are produced or released by damaged and dying cells, promotes sterile inflammation, which is important for tissue repair and regeneration, but can also lead to the development of numerous inflammatory diseases, such as metabolic disorders, neurodegenerative diseases, autoimmune diseases and cancer. Here we examine recent discoveries concerning the roles of DAMP-sensing receptors in sterile inflammation and in diseases resulting from dysregulated sterile inflammation, and then discuss insights into the cross-regulation of these receptors and their ligands.

中文翻译：

无菌炎症和炎性疾病中的DAMP感应受体。

先天免疫系统具有通过模式识别受体检测源自病原体的“非自身”分子（称为病原体相关分子模式）的能力。另外，已经发现越来越多的被称为损伤相关分子模式（DAMP）的内源性宿主衍生分子被各种先天性免疫受体感知。DAMPs的识别是由受损和垂死的细胞产生或释放的，可促进无菌炎症，这对于组织修复和再生很重要，但也会导致许多炎症性疾病的发展，例如代谢性疾病，神经退行性疾病，自身免疫性疾病疾病和癌症。

更新日期：2019-09-26

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