Recent advances in the biosynthesis of nucleoside antibiotics.,The Journal of Antibiotics

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Recent advances in the biosynthesis of nucleoside antibiotics.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-09-25 , DOI: 10.1038/s41429-019-0236-2
Taro Shiraishi ₁ , Tomohisa Kuzuyama _{1,

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Affiliation

Nucleoside antibiotics are a diverse class of natural products with promising biomedical activities. These compounds contain a saccharide core and a nucleobase. Despite the large number of nucleoside antibiotics that have been reported, biosynthetic studies on these compounds have been limited compared with those on other types of natural products such as polyketides, peptides, and terpenoids. Due to recent advances in genome sequencing technology, the biosynthesis of nucleoside antibiotics has rapidly been clarified. This review covering 2009-2019 focuses on recent advances in the biosynthesis of nucleoside antibiotics.

中文翻译：

核苷类抗生素生物合成的最新进展。

核苷类抗生素是一类具有良好生物医学活性的天然产物。这些化合物含有糖核心和核碱基。尽管已报道了大量核苷类抗生素，但与其他类型的天然产物（如聚酮化合物、肽和萜类化合物）相比，对这些化合物的生物合成研究受到限制。由于基因组测序技术的最新进展，核苷类抗生素的生物合成已被迅速阐明。本综述涵盖 2009-2019 年，重点关注核苷类抗生素生物合成的最新进展。

更新日期：2020-01-16

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