A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications,ACS Applied Materials & Interfaces

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A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-10-08 , DOI: 10.1021/acsami.9b15019
Pengzhong Shi _{1,

2,

3} , Jianghui Qin ₁ , Xiaoxiao Wu ₁ , Liwen Wang ₁ , Tinghong Zhang _{2,

3} , Dejun Yang _{2,

3} , Xingjie Zan _{1,

2,

3} , Dietmar Appelhans ₄

Affiliation

Proteins are considered to be one of the most important highly reproducible and monodisperse building blocks with specific functions in life sciences and material science. Protein capsules and their hybrids composed of protein–polymer conjugates have been intensively explored in drug delivery, catalysis, and cell-mimicking functions. Herein, we present a facile, universal, and efficient method to fabricate the diverse protein capsules, independent of the molecular weight (M_w), isoelectric points (IEP), wettability, amino acid sequence, and functional domains of enumerated proteins. The protein capsules were well characterized by various techniques. Furthermore, their ability to store the original protein functionality was demonstrated, which was mainly embodied in their enzyme responsiveness and good biocompatibility in vitro and in vivo. We believe that these protein capsules have multiple potential applications such as in drug delivery, tissue engineering, catalysis, and other application fields.

中文翻译：

一种简便而通用的方法，可以有效地制造用于多种潜在应用的各种蛋白质胶囊

蛋白质被认为是生命科学和材料科学中具有特定功能的最重要的高度可复制和单分散的构建基块之一。由蛋白质-聚合物共轭物组成的蛋白质胶囊及其杂种已在药物传递，催化和模拟细胞功能方面进行了深入研究。本文中，我们提出了一种简便，通用且有效的方法来制造各种蛋白质胶囊，而与分子量（M _w），等电点（IEP），润湿性，氨基酸序列和枚举蛋白质的功能域。通过各种技术对蛋白质胶囊进行了很好的表征。此外，还证明了它们存储原始蛋白质功能的能力，这主要体现在它们在体外和体内的酶反应性和良好的生物相容性。我们相信这些蛋白胶囊具有多种潜在的应用，例如在药物输送，组织工程，催化和其他应用领域。

更新日期：2019-10-10

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