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Relationship between preoperative high intraocular pressure and retinal nerve fibre layer thinning after glaucoma surgery.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-09-25 , DOI: 10.1038/s41598-019-50406-7 Woo-Jin Kim 1, 2 , Kyoung Nam Kim 1, 2 , Jae Yun Sung 1 , Jung Yeul Kim 1, 2 , Chang-Sik Kim 1, 2
Scientific Reports ( IF 3.8 ) Pub Date : 2019-09-25 , DOI: 10.1038/s41598-019-50406-7 Woo-Jin Kim 1, 2 , Kyoung Nam Kim 1, 2 , Jae Yun Sung 1 , Jung Yeul Kim 1, 2 , Chang-Sik Kim 1, 2
Affiliation
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Recent reports show varying results regarding peripapillary retinal nerve fibre layer (RNFL) thickness after intraocular pressure (IOP)-lowering glaucoma surgery. We hypothesised that different levels of the preoperative IOP influence RNFL thickness. A total of 60 patients (60 eyes) with glaucoma, who underwent glaucoma surgery and had a stable postoperative mean IOP < 22 mmHg, were enrolled. The RNFL thickness was measured using spectral domain optical coherence tomography, before and at 3-6 months after surgery. The preoperative peak IOP, 37.4 ± 10.8 mmHg, decreased to a postoperative mean IOP of 14.8 ± 3.5 mmHg (p < 0.001). The average RNFL thickness was significantly reduced from 75.6 ± 17.7 μm to 70.2 ± 15.8 μm (p < 0.001). In subgroup analyses, only patients with a preoperative peak IOP ≥ median value (37 mmHg) exhibited significant RNFL thinning (9.7 ± 6.6 μm, p < 0.001) associated with a higher preoperative peak IOP (r = 0.475, p = 0.008). The RNFL thinning was evident for a few months after glaucoma surgery in patients with a higher preoperative peak IOP, although the postoperative IOP was stable.
中文翻译：
青光眼手术后高眼压与视网膜神经纤维层变薄的关系。
最近的报告显示有关降低眼内压（IOP）的青光眼手术后的乳头周围视网膜神经纤维层（RNFL）厚度的不同结果。我们假设术前IOP的不同水平会影响RNFL厚度。总共纳入了60例（60眼）青光眼患者，他们接受了青光眼手术并且术后平均眼压稳定在<22 mmHg。在手术前和手术后3-6个月使用光谱域光学相干断层扫描仪测量RNFL厚度。术前眼压峰值为37.4±10.8 mmHg，降至术后平均IOP为14.8±3.5 mmHg（p <0.001）。RNFL的平均厚度从75.6±17.7μm显着降低到70.2±15.8μm（p <0.001）。在亚组分析中，只有术前峰值IOP≥中值（37 mmHg）的患者才显示出显着的RNFL变薄（9.7±6.6μm，p <0.001），同时术前峰值IOP更高（r = 0.475，p = 0.008）。尽管术后眼压稳定，但在青光眼手术后数月内，具有较高眼压的患者的RNFL变薄是明显的。
更新日期：2019-09-26
中文翻译：
青光眼手术后高眼压与视网膜神经纤维层变薄的关系。
最近的报告显示有关降低眼内压（IOP）的青光眼手术后的乳头周围视网膜神经纤维层（RNFL）厚度的不同结果。我们假设术前IOP的不同水平会影响RNFL厚度。总共纳入了60例（60眼）青光眼患者，他们接受了青光眼手术并且术后平均眼压稳定在<22 mmHg。在手术前和手术后3-6个月使用光谱域光学相干断层扫描仪测量RNFL厚度。术前眼压峰值为37.4±10.8 mmHg，降至术后平均IOP为14.8±3.5 mmHg（p <0.001）。RNFL的平均厚度从75.6±17.7μm显着降低到70.2±15.8μm（p <0.001）。在亚组分析中，只有术前峰值IOP≥中值（37 mmHg）的患者才显示出显着的RNFL变薄（9.7±6.6μm，p <0.001），同时术前峰值IOP更高（r = 0.475，p = 0.008）。尽管术后眼压稳定，但在青光眼手术后数月内，具有较高眼压的患者的RNFL变薄是明显的。
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