Synthesis ( IF 2.2 ) Pub Date : 2019-09-23 , DOI: 10.1055/s-0039-1690679 Oleg A. Rakitin 1, 2
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Abstract
The fast-growing interest in 1,2,5-thiadiazoles and their fused analogues including 2,1,3-benzothiadiazoles in recent years as important compounds in materials science and biomedicine has led to great progress in the synthesis of these heterocyclic systems. In this short review, the development of known procedures together with novel reactions is covered. New starting materials, unknown and unexpected transformations for the construction of the thiadiazole ring are emphasized.
1 Introduction
2 Synthesis of Monocyclic 1,2,5-Thiadiazoles
2.1 From 1,2-Diamines, vic-Dioximes and Related Compounds
2.2 From Alkyl Aryl (Hetaryl) Ketoximes and Tetrasulfur Tetranitride
2.3 By Condensation Reactions
2.4 From Other Heterocycles
3 Synthesis of Fused 1,2,5-Thiadiazoles
3.1 From ortho-Phenylenediamines and Related Compounds
3.2 From ortho-Aminonitroso and ortho-Aminonitro Derivatives
3.3 By Condensation Reactions
3.4 By Chalcogen Exchange in 1,2,5-Oxa- and 1,2,5-Selenadiazoles
3.5 Miscellaneous Methods
4 Conclusions
The fast-growing interest in 1,2,5-thiadiazoles and their fused analogues including 2,1,3-benzothiadiazoles in recent years as important compounds in materials science and biomedicine has led to great progress in the synthesis of these heterocyclic systems. In this short review, the development of known procedures together with novel reactions is covered. New starting materials, unknown and unexpected transformations for the construction of the thiadiazole ring are emphasized.
1 Introduction
2 Synthesis of Monocyclic 1,2,5-Thiadiazoles
2.1 From 1,2-Diamines, vic-Dioximes and Related Compounds
2.2 From Alkyl Aryl (Hetaryl) Ketoximes and Tetrasulfur Tetranitride
2.3 By Condensation Reactions
2.4 From Other Heterocycles
3 Synthesis of Fused 1,2,5-Thiadiazoles
3.1 From ortho-Phenylenediamines and Related Compounds
3.2 From ortho-Aminonitroso and ortho-Aminonitro Derivatives
3.3 By Condensation Reactions
3.4 By Chalcogen Exchange in 1,2,5-Oxa- and 1,2,5-Selenadiazoles
3.5 Miscellaneous Methods
4 Conclusions
中文翻译：
1,2,5-噻二唑和2,1,3-苯并噻二唑合成的最新进展
抽象的
近年来，对1,2,5-噻二唑及其稠合类似物（包括2,1,3-苯并噻二唑）作为材料科学和生物医学中的重要化合物的兴趣迅速增长，导致这些杂环系统的合成取得了巨大进展。在这篇简短的评论中，将介绍已知方法的开发以及新颖的反应。强调了噻二唑环的新原料，未知和意想不到的转变。
1引言
2单环1,2,5-噻二唑的合成
2.1从1,2-二胺，VIC -Dioximes和相关化合物
2.2从烷基芳基（杂芳基）酮肟和四硫四氮杂化物
2.3通过缩合反应
2.4来自其他杂环
3熔融1,2,5-噻二唑的合成
3.1来自邻苯二甲胺和相关化合物
3.2来自邻氨基亚硝基和邻氨基亚硝基衍生物
3.3通过缩合反应
3.4通过1,2,5-Oxa-和1,2,5-Selenadiazoles中的硫属元素交换
3.5其他方法
4。结论
近年来，对1,2,5-噻二唑及其稠合类似物（包括2,1,3-苯并噻二唑）作为材料科学和生物医学中的重要化合物的兴趣迅速增长，导致这些杂环系统的合成取得了巨大进展。在这篇简短的评论中，将介绍已知方法的开发以及新颖的反应。强调了噻二唑环的新原料，未知和意想不到的转变。
1引言
2单环1,2,5-噻二唑的合成
2.1从1,2-二胺，VIC -Dioximes和相关化合物
2.2从烷基芳基（杂芳基）酮肟和四硫四氮杂化物
2.3通过缩合反应
2.4来自其他杂环
3熔融1,2,5-噻二唑的合成
3.1来自邻苯二甲胺和相关化合物
3.2来自邻氨基亚硝基和邻氨基亚硝基衍生物
3.3通过缩合反应
3.4通过1,2,5-Oxa-和1,2,5-Selenadiazoles中的硫属元素交换
3.5其他方法
4。结论
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