Skeletal muscle is a highly adaptable tissue capable of changes in size, contractility, and metabolism according to functional demands. Atrophy is a decline in mass and strength caused by pathologic loss of myofibrillar proteins, and can result from disuse, aging, or denervation caused by injury or peripheral nerve disorders. We provide a high-quality longitudinal RNA-Seq dataset of skeletal muscle from a cohort of adult C57BL/6J male mice subjected to tibial nerve denervation for 0 (baseline), 1, 3, 7, 14, 30, or 90 days. Using an unbiased genomics approach to identify gene expression changes across the entire longitudinal course of muscle atrophy affords the opportunity to (1) establish acute responses to denervation, (2) detect pathways that mediate rapid loss of muscle mass within the first week after denervation, and (3) capture the molecular phenotype of chronically atrophied muscle at a stage when it is largely resistant to recovery.

骨骼肌是一种适应性很强的组织，能够根据功能需求改变大小、收缩性和新陈代谢。萎缩是由肌原纤维蛋白的病理性损失引起的质量和强度下降，可由废用、衰老或损伤或周围神经疾病引起的去神经支配引起。我们提供了一组高质量的骨骼肌纵向 RNA-Seq 数据集，该数据集来自一组接受胫神经去神经支配 0（基线）、1、3、7、14、30 或 90 天的成年 C57BL/6J 雄性小鼠。使用无偏见的基因组学方法来识别肌肉萎缩整个纵向过程中的基因表达变化，提供了机会 (1) 建立对去神经支配的急性反应，(2) 检测在去神经支配后第一周内介导肌肉质量快速损失的途径，