One-Pot-Three-Component Synthesis of 2-(1,2,3,4-Tetrahydroisoquinolin-1-yl)oxazoles via DEAD-Promoted Oxidative Ugi/Wittig Reaction.,The Journal of Organic Chemistry

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One-Pot-Three-Component Synthesis of 2-(1,2,3,4-Tetrahydroisoquinolin-1-yl)oxazoles via DEAD-Promoted Oxidative Ugi/Wittig Reaction.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-10-02 , DOI: 10.1021/acs.joc.9b02016
Mei Sun ₁ , Long Zhao ₁ , Ming-Wu Ding ₁

Affiliation

A new efficient DEAD-promoted oxidative Ugi/Wittig reaction for the preparation of 2-(1,2,3,4-tetrahydroisoquinolin-1-yl)oxazoles has been developed. The one-pot reactions of odorless isocyano(triphenylphosphoranylidene)acetates, carboxylic acids, and N-aryl-1,2,3,4-tetrahydroisoquinolines produced polysubstituted 2-(1,2,3,4-tetrahydroisoquinolin-1-yl)oxazoles directly in good yields in the presence of DEAD oxidant.

中文翻译：

通过DEAD促进的氧化Ugi / Wittig反应一锅三组分合成2-（1,2,3,4-四氢异喹啉-1-基）恶唑。

开发了一种新型的高效DEAD促进的氧化Ugi / Wittig反应，用于制备2-（1,2,3,4-四氢异喹啉-1-基）恶唑。无味的异氰酸氰基（三苯基膦亚基）乙酸酯，羧酸和N-芳基-1,2,3,4-四氢异喹啉的一锅法反应生成多取代的2-（1,2,3,4-四氢异喹啉-1-基）恶唑在存在DEAD氧化剂的情况下直接以高收率收割。

更新日期：2019-10-02

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