基于Pic的苦味酸化学传感器-智能手机设备设计的基础,Analytical Chemistry

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基于Pic的苦味酸化学传感器-智能手机设备设计的基础
Analytical Chemistry ( IF 6.7 ) Pub Date : 2019-09-30 , DOI: 10.1021/acs.analchem.9b03695
Arunkumar Kathiravan,Annasamy Gowri,Themmila Khamrang,Madhu Deepan Kumar,Namasivayam Dhenadhayalan,King-Chuen Lin,Marappan Velusamy,Madhavan Jaccob

开发用于选择性和灵敏地检测炸药的荧光探针是持续研究的主题。另外，检测机制背后的原理实际上是提供有关有效荧光探针设计的大量信息。在本文中，a系的1-（吡啶-2-基）咪唑[1,5- a研发了基于吡啶的荧光探针（TL18），并将其用作硝基炸药的荧光化学传感器。TL18的分子结构通过NMR和EI-MS光谱技术得到了很好的表征。紫外可见吸收，稳态和时间分辨荧光光谱技术已用于阐明TL18的光物理性质。探索了TL18探针的荧光性质，用于检测硝基炸药。有趣的是，与其他炸药相比，TL18探针对苦味酸具有选择性反应。苦味酸对TL18的荧光滴定研究的定量分析证明，该探针达到63 nM的检出限。此外，DFT和QTAIM研究用于确定TL18感应机制的性质。氢键相互作用是TL18赋予苦味酸命令性性能的原因。因此，我们的实验和理论研究为有效的荧光探针提供了充分和适当的先决条件。此外，开发了智能手机接口的便携式荧光计模块，以促进灵敏和实时感测苦味酸。该便携式模块能够检测低至99 nM的苦味酸。最终，这些研究将对新型爆炸物化学传感器的开发和应用产生重大影响。开发了智能手机接口的便携式荧光计模块，以促进灵敏和实时感测苦味酸。该便携式模块能够检测低至99 nM的苦味酸。最终，这些研究将对新型爆炸物化学传感器的开发和应用产生重大影响。开发了智能手机接口的便携式荧光计模块，以促进灵敏和实时感测苦味酸。该便携式模块能够检测低至99 nM的苦味酸。最终，这些研究将对新型爆炸物化学传感器的开发和应用产生重大影响。

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Pyrene-Based Chemosensor for Picric Acid—Fundamentals to Smartphone Device Design

Developing a fluorescent probe for the selective and sensitive detection of explosives is a topic of continuous research interest. Additionally, underlying the principles behind the detection mechanism is indeed providing substantial information about the design of an efficient fluorescence probe. In this context, a pyrene-tethered 1-(pyridin-2-yl)imidazo[1,5-a]pyridine-based fluorescent probe (TL18) was developed and employed as a fluorescent chemosensor for nitro explosives. The molecular structure of TL18 was well-characterized by NMR and EI-MS spectrometric techniques. UV–visible absorption, steady-state, and time-resolved fluorescence spectroscopic techniques have been employed to explicate the photophysical properties of TL18. The fluorescent nature of the TL18 probe was explored for detection of nitro explosives. Intriguingly, the TL18 probe was selectively responsive to picric acid over other explosives. The quantitative analysis of the fluorescence titration studies of TL18 with picric acid proved that the probe achieved a detection limit of 63 nM. Further, DFT and QTAIM studies were used to establish the nature of the sensing mechanism of TL18. The hydrogen-bonding interactions are the reason for the imperative sensing property of TL18 for picric acid. Thus, our experimental and theoretical studies provide an adequate and appropriate prerequisite for an efficient fluorescent probe. Furthermore, a smartphone-interfaced portable fluorimeter module is developed to facilitate sensitive and real-time sensing of picric acid. This portable module was capable of detecting picric acid down to 99 nM. Eventually, these studies will have a significant impact on development and application of a new class of chemosensors for detection of explosives.

更新日期：2019-09-30

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