The aim of this work is to investigate the three-component reaction of 6-aminopenicillinic acid, aldehydes and ammonium acetate. The work was used SiO₂-H₂SO₄ as a catalyst to promote the reaction under solvent-free conditions. A series of 5,5-dimethyl-2-(2-aryl-1H-imidazol-5-yl)-2,5-dihydrothiazole derivatives were obtained as the main product by this method.

中文翻译：

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通过开环/偶联/环化/脱羧级联反应制备含噻唑环的咪唑衍生物的新策略

这项工作的目的是研究6-氨基戊酸，醛和乙酸铵的三组分反应。使用SiO ₂ -H ₂ SO ₄作为催化剂在无溶剂条件下促进反应。通过该方法获得了一系列的5，5-二甲基-2-（2-芳基-1H-咪唑-5-基）-2，5-二氢噻唑衍生物作为主要产物。