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A shear-thinning adhesive hydrogel reinforced by photo-initiated crosslinking as a fit-to-shape tissue sealant.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-10-02 , DOI: 10.1039/c9tb01521c Shaoquan Bian 1 , Zhiqiang Zheng 1 , Yuan Liu 1 , Changshun Ruan 1 , Haobo Pan 1 , Xiaoli Zhao 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-10-02 , DOI: 10.1039/c9tb01521c Shaoquan Bian 1 , Zhiqiang Zheng 1 , Yuan Liu 1 , Changshun Ruan 1 , Haobo Pan 1 , Xiaoli Zhao 1
Affiliation
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Surgical sealants suitable for wounds with non-flat complex geometries are still a challenge to fulfill clinical requirements. Herein, a novel fit-to-shape sealant enhanced by photo-initiated crosslinking was developed utilizing maleic anhydride modified chitosan (MCS), benzaldehyde-terminated PEG (PEGDF) and polyethylene glycol diacrylate (PEGDA). Initially, the shear-thinning hydrogel prepared through the Schiff-base linkage between MCS and PEGDF could be injected into target sites, remolded to conform to a wound with non-flat complex geometry, and remain on the wound, avoiding adverse liquid leakage. Under illumination with ultra-violet (UV) light, the hydrogel was solidified in situ rapidly to adopt the wound contour and enhanced in adhesive strength to seal defects of the tissue. In addition, the hydrogel exhibits stability in extreme pH environments (pH = 1) and has potential to treat wounds inside the stomach with the existence of gastric acid. Moreover, the hydrogel can be applied as adhesive wound dressings through in situ 3D printing. Taken together, the fit-to-shape sealant enhanced by photo-initiated crosslinking can be considered as promising tissue adhesives for wound closure and other biomedical applications.
中文翻译：
通过光引发的交联而增强的剪切稀化型粘合剂水凝胶，可作为适合形状的组织密封胶。
适于具有非平坦复杂几何形状的伤口的外科手术密封剂仍然是满足临床要求的挑战。本文中，利用马来酸酐改性的壳聚糖（MCS），苯甲醛封端的PEG（PEGDF）和聚乙二醇二丙烯酸酯（PEGDA），开发了通过光引发的交联而增强的新型的适合形状的密封剂。最初，可以将通过MCS和PEGDF之间的席夫碱连接制备的剪切稀化水凝胶注入目标部位，重塑成型以适应具有非平坦复杂几何形状的伤口，并保留在伤口上，避免不利的液体泄漏。在紫外线（UV）照射下，水凝胶在原位迅速固化，以适应伤口轮廓，并增强粘合强度以密封组织的缺损。此外，该水凝胶在极端pH环境（pH = 1）下表现出稳定性，并且具有利用胃酸治疗胃内伤口的潜力。此外，水凝胶可通过原位3D打印用作伤口伤口敷料。综上所述，通过光引发的交联而增强的形状合适的密封剂可以被认为是用于伤口闭合和其他生物医学应用的有前途的组织粘合剂。
更新日期：2019-10-30
中文翻译：
通过光引发的交联而增强的剪切稀化型粘合剂水凝胶，可作为适合形状的组织密封胶。
适于具有非平坦复杂几何形状的伤口的外科手术密封剂仍然是满足临床要求的挑战。本文中，利用马来酸酐改性的壳聚糖（MCS），苯甲醛封端的PEG（PEGDF）和聚乙二醇二丙烯酸酯（PEGDA），开发了通过光引发的交联而增强的新型的适合形状的密封剂。最初，可以将通过MCS和PEGDF之间的席夫碱连接制备的剪切稀化水凝胶注入目标部位，重塑成型以适应具有非平坦复杂几何形状的伤口，并保留在伤口上，避免不利的液体泄漏。在紫外线（UV）照射下，水凝胶在原位迅速固化，以适应伤口轮廓，并增强粘合强度以密封组织的缺损。此外，该水凝胶在极端pH环境（pH = 1）下表现出稳定性，并且具有利用胃酸治疗胃内伤口的潜力。此外，水凝胶可通过原位3D打印用作伤口伤口敷料。综上所述，通过光引发的交联而增强的形状合适的密封剂可以被认为是用于伤口闭合和其他生物医学应用的有前途的组织粘合剂。
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