Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity,Phytochemistry

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Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
Phytochemistry ( IF 3.2 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.phytochem.2019.112127
Zengyuan Wang ₁ , Mengjun Jiang ₁ , Afsar Khan ₂ , Shengbao Cai ₁ , Xiaonian Li ₃ , Junqiu Liu ₄ , Guoyin Kai ₄ , Tianrui Zhao ₁ , Guiguang Cheng ₁ , Jianxin Cao ₁

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Five undescribed C21 pregnane glycosides, epigycosides D-H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 ± 6.4 μM. Epigycoside E also caused G0/G1 arrest, and inhibited TNF-α and IL-2 production.

中文翻译：

Epigynum cochinchinensis Epigynumgenane型孕烷苷及其免疫抑制活性

从 Epigynum cochinchinensis 的茎中分离出五种未描述的 C21 孕烷苷、epigycosides DH，以及四种已知的类似物、两种木脂素和一种类黄酮。使用光谱技术和酸水解阐明了孕烷苷的结构。针对Con A刺激的小鼠脾细胞增殖评估体外免疫活性。C21 孕烷苷以浓度依赖性方式显示免疫抑制活性。此外，epigycoside E 表现出有效的免疫抑制作用，对 Con A 刺激的小鼠脾细胞的 IC50 值为 22.1 ± 6.4 μM。Epigycoside E 还导致 G0/G1 期停滞，并抑制 TNF-α 和 IL-2 的产生。

更新日期：2019-12-01

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