Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media.,Nature Communications

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Spontaneous shrinking of soft nanoparticles boosts their diffusion in confined media.
Nature Communications ( IF 14.7 ) Pub Date : 2019-09-20 , DOI: 10.1038/s41467-019-12246-x
Pierre-Luc Latreille ₁ , Vahid Adibnia ₁ , Antone Nour _{1,

2} , Jean-Michel Rabanel _{1,

3} , Augustine Lalloz ₁ , Jochen Arlt ₄ , Wilson C K Poon ₄ , Patrice Hildgen ₁ , Vincent A Martinez ₄ , Xavier Banquy ₁

Affiliation

Improving nanoparticles (NPs) transport across biological barriers is a significant challenge that could be addressed through understanding NPs diffusion in dense and confined media. Here, we report the ability of soft NPs to shrink in confined environments, therefore boosting their diffusion compared to hard, non-deformable particles. We demonstrate this behavior by embedding microgel NPs in agarose gels. The origin of the shrinking appears to be related to the overlap of the electrostatic double layers (EDL) surrounding the NPs and the agarose fibres. Indeed, it is shown that screening the EDL interactions, by increasing the ionic strength of the medium, prevents the soft particle shrinkage. The shrunken NPs diffuse up to 2 orders of magnitude faster in agarose gel than their hard NP counterparts. These findings provide valuable insights on the role of long range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of more efficient NP-based transport systems.

中文翻译：

软纳米颗粒的自发收缩促进了它们在受限介质中的扩散。

改善纳米颗粒（NPs）跨生物屏障的运输是一项重大挑战，可以通过了解NPs在致密和密闭介质中的扩散来解决。在这里，我们报告了软NP在受限环境中收缩的能力，因此与坚硬，不可变形的颗粒相比，可以促进其扩散。我们通过在琼脂糖凝胶中嵌入微凝胶NPs来证明这种行为。收缩的起源似乎与围绕NP和琼脂糖纤维的静电双层（EDL）的重叠有关。实际上，已表明通过增加介质的离子强度来筛选EDL相互作用可防止软颗粒收缩。收缩的NP在琼脂糖凝胶中的扩散速度比硬NP快2个数量级。

更新日期：2019-09-21

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