AB loop engineered ferritin nanocages for drug loading under benign experimental conditions†,Chemical Communications

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AB loop engineered ferritin nanocages for drug loading under benign experimental conditions†
Chemical Communications ( IF 4.3 ) Pub Date : 2019-09-19 , DOI: 10.1039/c9cc05247j
Wenming Wang _{1,

2,

3,

4,

5} , Lele Wang _{1,

2,

3,

4,

5} , Guobang Li _{6,

7,

8} , Guanghua Zhao _{9,

10,

11} , Xuan Zhao _{1,

2,

3,

4,

5} , Hongfei Wang _{1,

2,

3,

4,

5}

Affiliation

Human ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH ≤ 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage.

中文翻译：

AB环工程铁蛋白纳米笼用于在良性实验条件下载药†

人铁蛋白已被研究为潜在的药物纳米载体，但是药物的封装需要极端条件（pH≤2.0）。在这里，通过工程化铁蛋白的AB环，我们获得了一个新的铁蛋白变体，没有新的孔，可以在pH 3.0或4.0时分解，在pH 7.0时重新组装。因此，在温和的条件下，可以将药物封装在这种新的铁蛋白纳米笼中。

更新日期：2019-10-10

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